Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Three-Compartment Open Model01:06

Three-Compartment Open Model

209
The three-compartment open model is a pharmacokinetic model used to describe the distribution and elimination of drugs following extravascular administration. It comprises a central compartment representing the plasma and two peripheral compartments. The highly perfused peripheral compartment represents organs and tissues with a rich blood supply, such as the liver, kidneys, and lungs. The scarcely perfused peripheral compartment represents tissues with lower blood supply, such as adipose...
209
Dynamic Equilibrium02:20

Dynamic Equilibrium

51.6K
A reversible chemical reaction represents a chemical process that proceeds in both forward (left to right) and reverse (right to left) directions. When the rates of the forward and reverse reactions are equal, the concentrations of the reactant and product species remain constant over time and the system is at equilibrium. A special double arrow is used to emphasize the reversible nature of the reaction. The relative concentrations of reactants and products in equilibrium systems vary greatly;...
51.6K
Clearance Models: Noncompartmental Models01:17

Clearance Models: Noncompartmental Models

57
Clearance is a pharmacokinetic parameter traditionally defined by compartment models, signifying the rate at which a drug is expelled from the body. However, a noncompartmental model offers an alternative method for assessing clearance, primarily employing empirical data obtained after administering a single drug dose.
The noncompartmental approach capitalizes on extensive sampling data, correlating the volume of distribution to systemic exposure and the administered dosage. This method enables...
57
Mechanistic Models: Overview of Compartment Models01:21

Mechanistic Models: Overview of Compartment Models

83
Mechanistic models, a category encompassing both physiological and compartmental modeling, differ from empirical models' approaches to incorporating known factors about the systems being modeled. Empirical models describe data with minimal assumptions, while mechanistic models aim to provide a robust description of available data by specifying assumptions and integrating known factors about the system. Compartmental analysis is a key example of a mechanistic model in pharmacokinetics and...
83
Two-Compartment Open Model: Overview01:05

Two-Compartment Open Model: Overview

131
Multicompartmental models are crucial tools in pharmacokinetics, providing a framework to understand how drugs move within the body. The two-compartment model is a crucial subtype, segmenting the body into central and peripheral compartments. The central compartment represents areas with high blood flow, such as plasma and highly perfused organs like the kidneys and liver, while the peripheral compartment signifies tissues with lower blood flow, like adipose tissue and muscle tissue.
The...
131
Steps in Outbreak Investigation01:18

Steps in Outbreak Investigation

125
In the ever-evolving field of public health, statistical analysis serves as a cornerstone for understanding and managing disease outbreaks. By leveraging various statistical tools, health professionals can predict potential outbreaks, analyze ongoing situations, and devise effective responses to mitigate impact. For that to happen, there are a few possible stages of the analysis:
125

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Long-Term Environmental Persistence and Phylogenetic Evidence of Burkholderia pseudomallei in a Melioidosis Case Cluster in Taiwan.

Tropical medicine & international health : TM & IH·2025
Same author

Pursuing equitable access to vaccines for the next epidemic.

Physical review. E·2024
Same author

Excitonic phases from Weyl semimetals.

Physical review letters·2012
See all related articles

Related Experiment Video

Updated: Jun 28, 2025

Setup of Consumer Wearable Devices for Exposure and Health Monitoring in Population Studies
15:00

Setup of Consumer Wearable Devices for Exposure and Health Monitoring in Population Studies

Published on: February 3, 2023

2.5K

Simplified model on the timing of easing the lockdown.

Sung-Po Chao1

  • 1Department of Physics, National Kaohsiung Normal University, Kaohsiung 82444, Taiwan, R.O.C.

Chinese Journal of Physics
|April 15, 2024
PubMed
Summary

Strict lockdowns are effective for controlling COVID-19 spread but costly. This study found that maintaining strict lockdowns for the longest possible duration minimizes overall economic impact during the pandemic.

Area of Science:

  • Epidemiology
  • Public Health
  • Health Economics

Background:

  • COVID-19 pandemic necessitated public health interventions like lockdowns.
  • Lockdowns successfully mitigated virus transmission but caused significant economic disruption.
  • Balancing public health and economic stability remains a critical challenge.

Purpose of the Study:

  • To model the spread of COVID-19 under lockdown conditions.
  • To evaluate the economic costs associated with pandemic-related workforce loss and medical expenses.
  • To determine the optimal lockdown strategy for minimizing economic impact.

Main Methods:

  • Utilized a modified Susceptible-Infectious-Recovered-Deceased (SIRD) epidemiological model.
  • Incorporated a time-dependent infection rate to simulate real-world transmission dynamics.
Keywords:
COVID-19EconomyLockdownSIRD Model

More Related Videos

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
10:46

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Published on: December 9, 2015

10.7K
Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses
03:53

Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses

Published on: November 10, 2023

1.1K

Related Experiment Videos

Last Updated: Jun 28, 2025

Setup of Consumer Wearable Devices for Exposure and Health Monitoring in Population Studies
15:00

Setup of Consumer Wearable Devices for Exposure and Health Monitoring in Population Studies

Published on: February 3, 2023

2.5K
A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
10:46

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Published on: December 9, 2015

10.7K
Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses
03:53

Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses

Published on: November 10, 2023

1.1K
  • Developed a simplified economic model to quantify financial losses.

    • Main Results:

    • Extended strict lockdown periods were found to be the most effective strategy for reducing economic costs.
    • The simulation indicated a direct correlation between lockdown duration and minimized economic burden.
    • The model highlights the trade-offs between public health measures and economic consequences.

    Conclusions:

    • Maintaining strict lockdowns for the longest feasible duration is the optimal strategy to minimize economic costs during a pandemic.
    • This approach balances the mitigation of virus spread with economic recovery.
    • Policy decisions should consider the long-term economic benefits of sustained public health measures.