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Persistent headache after COVID-19: Pathophysioloy, clinic and treatment
J A Membrilla1, E Caronna2,3, J Trigo-López4
1Unidad de Cefaleas Complejas y Dolor Neuropático, Servicio de Neurología, Hospital Universitario La Paz, Madrid, Spain.
Neurology Perspectives
|April 15, 2024
Summary
Persistent headaches are a common neurological symptom following COVID-19 infection. This review examines the causes and clinical features of long-term headaches after SARS-CoV-2, highlighting potential patient disability.
Area of Science:
- Neurology
- Infectious Diseases
- Public Health
Background:
- SARS-CoV-2 (the virus causing COVID-19) presents with diverse systemic symptoms beyond respiratory issues.
- Neurological manifestations, including frequent headaches, are observed during acute COVID-19.
- A growing number of recovered patients report persistent headaches, indicating a significant post-infection complication.
Purpose of the Study:
- To review the pathophysiological mechanisms of persistent headaches after COVID-19.
- To describe the clinical characteristics of post-COVID-19 headaches.
- To synthesize current literature and clinical experience on this emerging condition.
Main Methods:
- Literature review of studies on COVID-19 and associated headaches.
- Analysis of clinical data from patients experiencing persistent headaches post-COVID-19.
- Synthesis of pathophysiological and clinical information.
Main Results:
- Headache is a frequent acute symptom of SARS-CoV-2 infection.
- Persistent headaches can occur long after the acute phase of COVID-19.
- These prolonged headaches pose a significant challenge and risk of disability for affected individuals.
Conclusions:
- Persistent headache is a notable and potentially disabling sequela of COVID-19.
- Understanding the pathophysiology and clinical presentation is crucial for patient management.
- Further research is needed to address this growing public health concern.
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