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Natural compounds may contribute in preventing SARS-CoV-2 infection: a narrative review

Maria Eleonora Bizzoca1, Stefania Leuci2, Michele Davide Mignogna2

  • 1Department of Clinical and Experimental Medicine, University of Foggia, Foggia 71122, Italy.

Food Science and Human Wellness
|April 15, 2024
PubMed

Insights

Natural compounds show promise in combating Coronavirus disease 2019 (COVID-19) by interfering with viral replication and boosting the immune system. These plant-derived substances offer potential prophylactic and therapeutic benefits against SARS-CoV-2 infection.

Area of Science:

  • Virology
  • Pharmacology
  • Immunology

Background:

  • Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, is a global health crisis.
  • Current treatments primarily focus on supportive care and non-antiviral therapies.
  • Vaccination remains a key preventive measure, but antiviral alternatives are crucial.

Purpose of the Study:

  • To conduct a narrative review of existing literature.
  • To summarize natural compounds with potential antiviral activity against SARS-CoV-2.
  • To elucidate the mechanisms of action of these natural compounds.

Main Methods:

  • Literature search of current scientific publications.
  • Narrative review methodology.
  • Synthesis of findings on natural compounds and their antiviral effects.

Main Results:

  • Medicinal plants and their extracts exhibit antiviral properties.
  • Natural compounds can inhibit viral entry, replication, and assembly.
  • These substances can modulate the host immune system and reduce inflammation.

Conclusions:

  • Natural compounds represent a promising avenue for COVID-19 treatment and prevention.
  • Further research into phytochemicals could lead to novel antiviral drugs.
  • These natural agents may serve as prophylactic or therapeutic options for at-risk individuals.
Keywords:
COVID-19Infectious diseaseMedicinal plantsNatural compoundsPhytochemicalsPreventionSARS-CoV-2

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