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Related Concept Videos

Imaging Biological Samples with Optical Microscopy01:18

Imaging Biological Samples with Optical Microscopy

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Optical microscopy uses optic principles to provide detailed images of samples. Antonie van Leeuwenhoek designed the first compound optical microscope in the 17th century to visualize blood cells, bacteria, and yeast cells. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes with enhanced magnification and resolution.
In optical microscopy, the specimen to be viewed is placed on a glass slide and clipped on the stage...
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Overview of Microscopy Techniques01:22

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The early pioneers of microscopy opened a window into the invisible world of microorganisms. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes that leveraged nonvisible light, such as fluorescence microscopy that uses an ultraviolet light source and electron microscopy that uses short-wavelength electron beams. These advances significantly improved magnification, image resolution, and contrast. By comparison, the...
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Confocal Fluorescence Microscopy01:16

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Confocal microscopy is an advanced microscopic technique. The prime advantage of the confocal microscope over other microscopy techniques is its ability to block the out-of-focus light from the illuminated samples using pinholes. It is widely used with fluorescence optics to obtain high-resolution, sharp contrast images. Unlike optical microscopes, confocal microscopes use a focused beam of light laser to scan the entire sample surface at different z-planes. These microscopes are, therefore,...
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Overview of Electron Microscopy01:25

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The wavelengths of visible light ultimately limit the maximum theoretical resolution of images created by light microscopes. Most light microscopes can only magnify 1000X, and a few can magnify up to 1500X. Electrons, like electromagnetic radiation, can behave like waves, but with wavelengths of 0.005 nm, they produce significantly greater resolution up to 0.05 nm as compared to 500 nm for visible light. An electron microscope (EM) can create a sharp image that is magnified up to 2,000,000X.
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Phase Contrast and Differential Interference Contrast Microscopy01:26

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Phase-Contrast Microscopes
In-phase-contrast microscopes, interference between light directly passing through a cell and light refracted by cellular components is used to create high-contrast, high-resolution images without staining. It is the oldest and simplest type of microscope that creates an image by altering the wavelengths of light rays passing through the specimen. Altered wavelength paths are created using an annular stop in the condenser. The annular stop produces a hollow cone of...
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Super-resolution Fluorescence Microscopy01:37

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Super-resolution fluorescence microscopy (SRFM) provides a better resolution than conventional fluorescence microscopy by reducing the point spread function (PSF). PSF is the light intensity distribution from a point that causes it to appear blurred. Due to PSF, each fluorescing point appears bigger than its actual size, and it is the PSF interference of nearby fluorophores that causes the blurred image. Various approaches to achieving higher resolution through SRFM have recently been...
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Major Components of the Light Microscope
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The InSciEdRS View: A User-Friendly and Accessible Microscope with Easy-to-Follow Companion Curricula.

Soaleha Shams1,2, Sidney Olson1,2, Michael P Ekker1,2

  • 1InSciEd Out Foundation, Rochester, Minnesota, USA.

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|April 15, 2024
PubMed
Summary

The InSciEdRS View microscope offers an affordable, user-friendly alternative for K-12 science education. This accessible tool, paired with new curricula, enhances hands-on learning for all students.

Keywords:
K-12 educationmodular curriculascience educationstudent microscope

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Area of Science:

  • Educational Technology
  • Microscopy
  • K-12 Science Education

Background:

  • Microscopes are vital for science education but are often inaccessible in K-12 classrooms due to cost and complexity.
  • Existing barriers hinder widespread adoption of microscopy in schools.

Purpose of the Study:

  • To introduce the InSciEdRS View, an innovative microscope designed for K-12 science education.
  • To address the financial, complexity, and training barriers associated with traditional microscopes.

Main Methods:

  • Developed the InSciEdRS View microscope in collaboration with Area 10 Labs.
  • Integrated a 1080p camera, Wi-Fi/USB connectivity, and a portable design.
  • Created accompanying K-12 curricula using larval zebrafish for hands-on observation.

Main Results:

  • The InSciEdRS View offers 10×-50× magnification with user-friendly operation.
  • Its design is robust for classrooms and flexible for lab or fieldwork.
  • Developed scalable and accessible curricula for diverse learners.

Conclusions:

  • The InSciEdRS View microscope and InSciEd Out curricula provide an accessible solution to enhance science education.
  • This integrated approach promotes active learning and better outcomes for all students, including neurodiverse learners.