Electrolytic current parameters in the dorsolateral tegmental obesity syndrome in rats

Female rats received lesions in the dorsolateral tegmentum formed by the 20 sec passage of 0.25, 0.5, or 0.75 mA anodal or 0.5, 0.75, 1.0, 1.25, or 1.5 mA cathodal current. Although all lesion parameters induced roughly comparable body weight gains, the largest effect was seen with 1.25 mA cathodal current. Anodal lesions were much larger and induced transient periods of hyperactivity that confounded the effects of the lesions on body weight gain.