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Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

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Are Deep Odontogenic Infections Associated With an Increased Risk for Sepsis?

Austin T Bond¹, Yasmine S Soubra², Umaymah Aziz²

¹Dental Student Researcher, Department of Oral & Maxillofacial Surgery, Texas A&M School of Dentistry, Dallas, TX.

Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons

|April 15, 2024

Summary

This summary is machine-generated.

Deep odontogenic infections (OI) significantly increase sepsis risk compared to superficial ones. Early identification of OI location is crucial for sepsis risk assessment using the Quick Sequential Organ Failure Assessment (qSOFA) score.

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Area of Science:

Medical research
Infectious disease
Sepsis research

Background:

The Quick Sequential Organ Failure Assessment (qSOFA) is a recommended tool for sepsis identification.
Odontogenic infections (OI) can escalate to sepsis, leading to systemic inflammation or organ failure.

Purpose of the Study:

To evaluate the association between the anatomical location of odontogenic infections and the risk of sepsis upon hospital admission.

Main Methods:

A retrospective cohort study analyzed patients treated for OI under general anesthesia.
OI location was categorized as superficial or deep, with deep infections showing a higher sepsis risk.
Sepsis risk was primarily assessed using the qSOFA score.

Main Results:

Deep OI presented a 5.4 times greater relative risk for a positive qSOFA score (indicating sepsis risk) compared to superficial OI.
Adjusted analyses revealed a significant correlation between OI laterality, number of involved spaces, and qSOFA score (OR=9.13).

Conclusions:

The anatomical location of odontogenic infections is significantly associated with an increased risk of sepsis, as indicated by qSOFA scores.
Findings highlight the importance of OI location in predicting sepsis risk and guiding clinical management.