[Highly polar chemical constituents from whole herb of Scindapsus officinalis]

Macroporous resin column chromatography, MCI medium pressure column chromatography, and semi-preparative high performance liquid chromatography were employed to isolate the chemical components from the aqueous extract of the whole herb of Scindapsus officinalis. The structures of the compounds were identified based on the physical and chemical properties and the spectroscopic data. Ten compounds were isolated from the aqueous extract and identified as 3,4-dihydroxyphenylethyl-8-O-[β-D-apiofuranosyl-(1→4)]-β-D-glucopyranoside(1), alternamide B(2), 3,4-dihydroxyphenylethyl-O-β-D-glucopyranoside(3), 1-(4-hydroxy)-phenylethyl-β-D-galactopyranoside(4), 3,4-dihydroxyphenylethyl-8-O-[β-D-apiofuranosyl-(1→2)]-β-D-glucopyranoside(5), hydroxytyrosol-4-O-β-D-glucopyranoside(6), 3,5-dihydroxyphenylethyl-3-O-β-D-glucopyranoside(7), salidroside(8), dihydroisoquinolone(9), and 4-methoxybenzenepropanol-3-O-β-D-glucopyranoside(10). Among them, compound 1 was a new one, and compounds 2-10 were obtained from S. officinalis for the first time. The RAW264.7 cells were exposed to lipopolysaccharide for the mode-ling of inflammation, and the cells were then used to examine anti-inflammatory activities of the compounds. The results showed that compounds 6 and 7 had strong anti-inflammatory activities, while compounds 1, 2, and 5 had moderate anti-inflammatory activities.