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UBXN11 Predicts as a Poor Index for Colorectal Cancer and Contributes to the Tumorigenesis by Activating NF-κB
Xiangbo Chen1, Changxin Chen1, Rensong He1
1Endoscopy Center, Quanzhou First Hospital Affiliated to Fujian Medical University, No. 250 East Street, Licheng District, Quanzhou, 362000, Fujian, China.
Digestive Diseases and Sciences
|April 15, 2024
Summary
UBXN11 promotes colorectal cancer (CRC) growth and progression by activating the NF-κB pathway. Targeting UBXN11 may offer new therapeutic strategies for CRC treatment.
Area of Science:
- Oncology
- Molecular Biology
- Cancer Research
Background:
- Colorectal cancer (CRC) pathogenesis is complex and not fully understood.
- The specific role of UBXN11 in CRC development requires further investigation.
Purpose of the Study:
- To elucidate the role of UBXN11 in colorectal cancer (CRC) progression.
- To investigate the underlying molecular mechanisms by which UBXN11 influences CRC.
Main Methods:
- Analyzed UBXN11 expression and survival data in CRC and other cancers using the UALCAN database.
- Utilized human CRC cell lines and a xenograft mouse model with UBXN11 overexpression.
- Performed luciferase assays, qPCR, and Western blot to examine UBXN11 and NF-κB signaling interactions.
Main Results:
- Elevated UBXN11 expression was found in digestive tract tumors, correlating with poorer overall survival in CRC patients.
- UBXN11 overexpression enhanced CRC cell proliferation in vitro and tumor growth in vivo.
- UBXN11 promotes CRC tumorigenesis via increased activation of the NF-κB signaling pathway.
Conclusions:
- UBXN11 plays a critical role in colorectal cancer progression.
- UBXN11 may serve as a potential therapeutic target for CRC treatment.
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