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Related Concept Videos

Positron Emission Tomography01:29

Positron Emission Tomography

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Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
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  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Prognostic Value Of Pre-treatment [18f] Fdg Pet/ct In Recurrent Nasopharyngeal Carcinoma Without Distant Metastasis

Prognostic value of pre-treatment [18F] FDG PET/CT in recurrent nasopharyngeal carcinoma without distant metastasis

Zhe Dong1, Gao-Yuan Wang1, Dong-Yu Dai1

  • 1Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, 510060, Guangzhou, P. R. China.

BMC Cancer
|April 15, 2024

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Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
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Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT

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Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
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Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates

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Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer
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Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer

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View abstract on PubMed

Summary
This summary is machine-generated.

Positron emission tomography/computed tomography (PET/CT) improves overall survival for patients with locoregional recurrent nasopharyngeal cancer (lrNPC) in advanced stages. This diagnostic tool is effective for assessing recurrent staging and guiding treatment decisions.

Area of Science:

  • Oncology
  • Nuclear Medicine
  • Radiology

Background:

  • [18F]-Fluorodeoxyglucose (FDG) PET/CT detects recurrence and metastasis in nasopharyngeal cancer (NPC).
  • Assessing the prognostic value of PET/CT in locoregional recurrent NPC (lrNPC) is crucial for treatment planning.

Purpose of the Study:

  • To evaluate the prognostic significance of PET/CT in patients with locoregional recurrent nasopharyngeal cancer (lrNPC).
  • To determine if PET/CT improves overall survival (OS) outcomes in lrNPC patients.

Main Methods:

  • Retrospective analysis of 451 patients with recurrent I-IVA NPC (April 2009-December 2015).
  • Comparison of overall survival (OS) between patients with and without PET/CT, stratified by initial and recurrent staging (MRI-based).

Main Results:

Keywords:
Locoregional recurrentNasopharyngeal carcinomaTNM[18F] FDG PET/CT

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Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
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Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer
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  • PET/CT use was associated with significantly higher OS rates in III-IVA and rIII-IVA NPC cohorts (univariate analysis).
  • PET/CT was an independent predictor of OS in the rIII-IVA cohort (HR=0.476, P=0.012).
  • Patients with rIII-IVA NPC receiving PET/CT before salvage surgery showed better prognosis than MRI alone (P=0.036). Recurrent stage by PET/CT independently predicted OS.

Conclusions:

  • PET/CT can improve overall survival for patients with rIII-IVA NPC.
  • PET/CT is an effective tool for assessing recurrent TNM staging in NPC.