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High-throughput Identification of Bacteria Repellent Polymers for Medical Devices

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Biofilm Inhibition on Medical Devices and Implants Using Carbon Dots: An Updated Review.

Eepsita Priyadarshini¹, Rohit Kumar², Kalpana Balakrishnan³

¹School of Environmental Sciences, Jawaharlal Nehru University, New Delhi 110067, India.

ACS Applied Bio Materials

|April 16, 2024

Summary

Carbon dots (CDs) show promise in combating biofilm infections on medical devices. These nanoparticles effectively inhibit pathogenic bacteria and disrupt biofilms, offering new strategies for infection control.

Keywords:

Biofilm Carbon dots Exopolysaccharides Medical implants Pathogenic microbes Quorum sensing

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Oral Biofilm Formation on Different Materials for Dental Implants

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Published on: June 24, 2018

Area of Science:

Biomaterials Science
Nanotechnology
Microbiology

Background:

Biofilms are microbial communities on surfaces, causing persistent infections resistant to drugs.
Biofilm infections on medical implants pose a significant global health threat.
Current treatments struggle against the protective exopolysaccharide matrix of biofilms.

Purpose of the Study:

To review the mechanisms of biofilm formation on medical implants.
To survey major biofilm-forming pathogens and associated infections.
To highlight the anti-biofilm properties of carbon dots (CDs) as potential medical implant coatings.

Main Methods:

Literature review on biofilm formation and carbon dot applications.
Analysis of carbon dot mechanisms against microbial growth and biofilm matrices.
Survey of studies demonstrating carbon dot efficacy against key pathogenic bacteria.

Main Results:

Carbon dots (CDs) possess antimicrobial properties and can penetrate microbial cells.
CDs inhibit bacterial growth via cytoplasmic leakage, ROS generation, and DNA fragmentation.
CDs have shown efficacy against biofilms of *Escherichia coli*, *Staphylococcus aureus*, and *Pseudomonas aeruginosa*.

Conclusions:

Carbon dots offer a novel approach to combatting biofilm infections on medical implants.
CD-based coatings and hydrogels can enhance treatment efficacy and reduce healthcare costs.
Further development of CD applications holds significant potential for preventing implant-associated infections.