Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Management of Insomnia01:19

Management of Insomnia

244
The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
244
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. The Effect Of Melatonin On Increasing The Health Related Quality Of Life In Non-metastatic Breast Cancer Patients: Three-year Follow Up A Clinical Trial

The Effect of Melatonin on Increasing the Health Related Quality of Life in Non-Metastatic Breast Cancer Patients: Three-Year Follow up a Clinical Trial

Zahra Keshtpour Amlashi1, Fatemeh Sheida1, Robab Anbiaee2

  • 1Cancer Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.

Integrative Cancer Therapies
|April 16, 2024

Related Experiment Videos

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue
08:56

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue

Published on: May 17, 2018

9.1K
Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
04:33

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression

Published on: April 26, 2024

673
Heat-sensitive Moxibustion as a Traditional Chinese Medicine Therapy for Chronic Obstructive Pulmonary Disease Combined with Insomnia
04:59

Heat-sensitive Moxibustion as a Traditional Chinese Medicine Therapy for Chronic Obstructive Pulmonary Disease Combined with Insomnia

Published on: May 30, 2025

208

View abstract on PubMed

Summary
This summary is machine-generated.

Long-term melatonin use significantly improved the quality of life for breast cancer patients. This study found that 18mg of melatonin daily for three years enhanced health-related quality of life (HRQoL) in non-metastatic breast cancer survivors.

Area of Science:

  • Oncology
  • Pharmacology
  • Quality of Life Research

Background:

  • Breast cancer significantly impacts patients' quality of life, often leading to fatigue and sleep disturbances.
  • Melatonin, a hormone regulating sleep-wake cycles, is being investigated for its potential to alleviate these symptoms.

Purpose of the Study:

  • To evaluate the long-term effect of melatonin supplementation on health-related quality of life (HRQoL) in patients with non-metastatic breast cancer.
  • To determine if daily melatonin intake can improve HRQoL compared to a placebo.

Main Methods:

  • A 3-year randomized controlled trial involving 184 non-metastatic breast cancer patients.
  • Participants received either 18mg of melatonin daily or a placebo.
  • Health-related quality of life was assessed using the EORTC QLQ-C30 questionnaire at baseline, 2 months, and 3 years.
Keywords:
EORTCbreast cancerlong-termmelatonin

Related Experiment Videos

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue
08:56

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue

Published on: May 17, 2018

9.1K
Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
04:33

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression

Published on: April 26, 2024

673
Heat-sensitive Moxibustion as a Traditional Chinese Medicine Therapy for Chronic Obstructive Pulmonary Disease Combined with Insomnia
04:59

Heat-sensitive Moxibustion as a Traditional Chinese Medicine Therapy for Chronic Obstructive Pulmonary Disease Combined with Insomnia

Published on: May 30, 2025

208

Main Results:

  • The general HRQoL score showed significant improvement over time in the melatonin group compared to the placebo group.
  • A statistically significant difference (P < .05) in HRQoL was observed between the melatonin and placebo groups.
  • Melatonin intervention led to a better overall quality of life for breast cancer patients.

Conclusions:

  • Long-term daily intake of 18mg melatonin for three years is effective in improving the quality of life for patients with non-metastatic breast cancer.
  • Melatonin supplementation may be a viable supportive therapy to enhance HRQoL in this patient population.
  • Further research can explore optimal melatonin dosages and its impact on specific symptoms like fatigue and sleep disorders.
quality of life