Related Experiment Video
Updated: Aug 7, 2026

11:11
Longitudinal Measurement of Extracellular Matrix Rigidity in 3D Tumor Models Using Particle-tracking Microrheology
Published on: June 10, 2014
Longitudinal soft-tissue profile changes: a study of three analyses
American Journal of Orthodontics
|September 1, 1985
Summary
Orthodontic soft-tissue analysis reveals distinct age and sex differences in facial convexity, Holdaway, and Merrifield
Area of Science:
- Orthodontics
- Cephalometric analysis
- Facial growth and development
Background:
- Orthodontic diagnosis and treatment planning rely on soft-tissue parameters.
- Evaluating profile changes during growth and treatment is crucial.
- Existing cephalometric standards may not account for age and sex variations.
Purpose of the Study:
- To describe changes in six key soft-tissue parameters during growth.
- To analyze age- and sex-specific variations in these parameters.
- To establish age- and sex-specific cephalometric standards for orthodontists.
Main Methods:
- Lateral cephalograms from 35 subjects (20 males, 15 females) aged 5-25 years were analyzed.
- Six soft-tissue parameters were evaluated: facial convexity angles, Holdaway soft-tissue angle, Merrifield's Z angle, and Rickett's esthetic line/lip relationships.
- Descriptive statistics, growth profile curves, and regression equations were used to analyze age-related changes.
Main Results:
- Significant differences were observed between male and female growth curves for most parameters, except for facial convexity (excluding nose) and Merrifield's Z angle.
- Soft-tissue facial convexity angles, Holdaway soft-tissue angle, and Merrifield's Z angle showed dissimilar age-related behavior.
- Age- and sex-specific cephalometric standards were identified for each parameter.
Conclusions:
- Orthodontists should utilize multiple soft-tissue parameters for comprehensive profile evaluation.
- The identified age- and sex-specific standards aid in tailoring orthodontic treatment to individual patient norms.
- This approach allows for treatment targeting age- and sex-specific soft-tissue norms, moving beyond generalized adult standards.

