Microbial perspective on the skin-gut axis and atopic dermatitis

Area of Science:

• Microbiology
• Immunology
• Dermatology

Background:

• Atopic dermatitis (AD) is a prevalent, relapsing inflammatory skin condition with complex causes.
• Advances in sequencing and genomics reveal links between AD, skin, and gut microbiota.
• The gut-brain-skin axis and its communication pathways are increasingly understood.

Purpose of the Study:

• To review the role of the microbiota-skin-gut axis in atopic dermatitis.
• To explore signaling molecules and pathways involved in AD pathogenesis.
• To focus on therapeutic strategies targeting the microbiota for AD treatment.

Main Methods:

• Literature review focusing on the microbiota-skin-gut axis and AD.
• Analysis of studies on signaling molecules and pathways.
• Examination of interventions including probiotics, antimicrobial peptides (AMPs), and microbiota transplantation.

Main Results:

• The microbiota-skin-gut axis significantly influences allergic skin inflammation in AD.
• Specific microbial compositions and their metabolites impact AD.
• Various interventions show potential for modulating the microbiota to alleviate AD symptoms.

Conclusions:

• The microbiota-skin-gut axis is a critical factor in atopic dermatitis.
• Targeting microbial imbalances offers a promising therapeutic avenue for AD.
• Further research into microbiota-based interventions is warranted for allergic skin inflammation.