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Reporting quality of heart failure randomized controlled trials 2000-2020: Temporal trends in adherence to CONSORT

Mohamed B Jalloh1, Veronica A Bot2, Cristiana Z Borjaille1

  • 1Department of Medicine, McMaster University, Hamilton, ON, Canada.

European Journal of Heart Failure
|April 16, 2024
PubMed

Insights

Reporting quality in heart failure (HF) randomized controlled trials (RCTs) has improved but remains suboptimal. Adherence to the CONSORT statement for RCT reporting increased over 20 years, yet gaps persist.

Area of Science:

  • Cardiology
  • Clinical Trials Methodology
  • Health Services Research

Background:

  • Heart failure (HF) significantly impacts older adults' morbidity and mortality.
  • Accurate interpretation of HF randomized controlled trials (RCTs) relies on transparent reporting.
  • The CONsolidated Standards Of Reporting Trials (CONSORT) statement guides RCT reporting quality.

Purpose of the Study:

  • To evaluate the reporting quality of HF RCTs in high-impact journals.
  • To assess adherence to CONSORT guidelines in HF RCTs.
  • To examine trends and factors influencing CONSORT adherence over time.

Main Methods:

  • Searched MEDLINE, EMBASE, and CINAHL for HF RCTs published 2000-2020 in high-impact journals.
  • Assessed adherence to CONSORT criteria (2010 update and original 1996 criteria).
  • Used statistical tests (Jonckheere-Terpstra, multivariable linear regression) to analyze temporal trends and influencing factors.

Main Results:

  • A total of 221 HF RCTs were analyzed, with suboptimal overall mean adherence (69.7%).
  • Adherence significantly increased over the 20-year study period (p < 0.001).
  • Factors associated with higher adherence included later publication (post-2010), two-group parallel randomization, and multicenter trials. Higher CONSORT adherence correlated with higher journal impact factors (r=0.312).

Conclusions:

  • Reporting quality in HF RCTs has improved but remains suboptimal.
  • Continued efforts are needed to enhance adherence to CONSORT guidelines for transparent and accurate reporting of HF research.
Abstract

Keywords:
CONSORT guidelinesHeart failure

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