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Maurice Pasternak^1,2, Saira S Mirza¹, Nicholas Luciw^1,3

¹Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Ontario, Canada.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association

|April 16, 2024

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Summary

This summary is machine-generated.

Cerebral perfusion decline tracks genetic frontotemporal dementia (FTD) progression before symptoms appear. Specific regional hypoperfusion patterns emerge in different genetic FTD subtypes, with the left thalamus affected across all groups.

Area of Science:

Neuroimaging
Neurology
Biomarker Discovery

Context:

Genetic frontotemporal dementia (FTD) lacks effective longitudinal biomarkers for its presymptomatic phase.
Early detection and tracking of disease progression are crucial for intervention strategies.

Purpose:

To investigate the utility of cerebral perfusion as a biomarker in presymptomatic carriers of genetic FTD.
To analyze longitudinal changes in cerebral perfusion across different genetic FTD subtypes (C9orf72, GRN, MAPT).

Summary:

Longitudinal arterial spin labeling MRI revealed global gray matter perfusion decline in all presymptomatic genetic FTD groups.
Distinct regional hypoperfusion patterns were observed, with the left thalamus commonly affected.
Individuals who converted to symptomatic FTD showed greater right frontal hypoperfusion compared to asymptomatic carriers.

Keywords:

arterial spin labeling cerebral perfusion frontotemporal dementia presymptomatic biomarker

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Impact:

Cerebral perfusion serves as a potential early biomarker for identifying and monitoring genetic FTD and its subtypes before symptom onset.
Understanding regional perfusion changes can aid in differentiating genetic FTD trajectories.