Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

High-Performance Liquid Chromatography: Instrumentation

High-Performance Liquid Chromatography: Instrumentation

High-performance liquid chromatography, or HPLC, is an analytical technique that separates liquid samples under high pressures. An HPLC instrument consists of glass bottles for storing solvents called mobile phase reservoirs. HPLC-grade solvents are used to maintain high purity, and the dissolved gases are removed using a degasser, such as a vacuum pumping system or sparging with helium. The solvents are then pumped into the analytical column using a screw-driven syringe or reciprocating pumps.

Inductively Coupled Plasma Atomic Emission Spectroscopy: Instrumentation

Inductively Coupled Plasma Atomic Emission Spectroscopy: Instrumentation

Inductively coupled plasma (ICP) is the common plasma source used in atomic emission spectroscopy (AES), a technique that detects and analyzes various elements in a sample. This method is often called inductively coupled plasma atomic emission spectroscopy (ICP-AES).
There are three main types of inductively coupled plasma atomic emission spectroscopy (ICP-AES) instruments: sequential, simultaneous multichannel, and Fourier transform instruments, with the latter being less commonly used....

Inductively Coupled Plasma–Mass Spectrometry (ICP–MS): Overview

Inductively Coupled Plasma–Mass Spectrometry (ICP–MS): Overview

In inductively coupled plasma–mass spectrometry (ICP–MS), an inductively coupled plasma (ICP) torch is used as an atomizer and ionizer. Solid samples are dissolved and volatilized before being introduced into the high-temperature argon plasma, while solution samples are nebulized and passed through the high-temperature argon plasma. Plasma dissociates the analytes and ionizes their component atoms to form a mixture of positive ions and molecular species. The positive ions are then...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Advancing non-faradaic impedance biosensors: sensitivity enhancement strategies using microfluidics, multiscale labeling, and CMOS technology.

Microsystems & nanoengineering·2026

Same author

Stabilization of adhesions controls F-actin architecture in mechanotransduction.

Communications materials·2025

Same author

Regulation of corneal stromal cell behavior by modulating curvature using a hydraulically-controlled organ chip array.

Nature communications·2025

Same author

Microfabricated Onsite Analyzer for Biomarkers (MOAB) for Automated Crew Health Monitoring.

ACS sensors·2025

Same author

Current and Future Cornea Chip Models for Advancing Ophthalmic Research and Therapeutics.

Advanced biology·2025

Same author

How should we fund end-of-life care in the US?

Lancet regional health. Americas·2023

Search research articles

Related Experiment Video

Updated: Jun 28, 2025

A Microfluidic Chip for ICPMS Sample Introduction

A Microfluidic Chip for ICPMS Sample Introduction

Published on: March 5, 2015

Integrated high performance microfluidic organic analysis instrument for planetary and space exploration.

Anna L Butterworth¹, Matin Golozar^2,3, Zachary Estlack³

¹Space Sciences laboratory, University of California Berkeley, Berkeley, CA 94720, USA. butterworth@berkeley.edu.

|April 16, 2024

Summary

Scientists developed a Microfluidic Organic Analyzer (MOA) for space exploration. This sensitive instrument detects organic molecules and potential biosignatures in extraterrestrial environments, aiding the search for habitable regions.

More Related Videos

Atmospheric-pressure Molecular Imaging of Biological Tissues and Biofilms by LAESI Mass Spectrometry

Atmospheric-pressure Molecular Imaging of Biological Tissues and Biofilms by LAESI Mass Spectrometry

Published on: September 3, 2010

Author Spotlight: Characterization of Low-Affinity Protein Interactions in Solution Using MassFluidix Technology

Author Spotlight: Characterization of Low-Affinity Protein Interactions in Solution Using MassFluidix Technology

Published on: January 26, 2024

Related Experiment Videos

Last Updated: Jun 28, 2025

A Microfluidic Chip for ICPMS Sample Introduction

A Microfluidic Chip for ICPMS Sample Introduction

Published on: March 5, 2015

Atmospheric-pressure Molecular Imaging of Biological Tissues and Biofilms by LAESI Mass Spectrometry

Atmospheric-pressure Molecular Imaging of Biological Tissues and Biofilms by LAESI Mass Spectrometry

Published on: September 3, 2010

Author Spotlight: Characterization of Low-Affinity Protein Interactions in Solution Using MassFluidix Technology

Author Spotlight: Characterization of Low-Affinity Protein Interactions in Solution Using MassFluidix Technology

Published on: January 26, 2024

Area of Science:

Astrobiology and Planetary Science
Analytical Chemistry and Instrumentation

Background:

Exploring solar system's organic inventory is key to identifying habitable regions and searching for extraterrestrial life.
Performing high-resolution, high-sensitivity chemical analyses in space and planetary environments presents significant challenges.

Purpose of the Study:

To develop a sensitive, automated, and flight-capable instrument for analyzing organic molecules in extraterrestrial environments.
To enable autonomous sample-in to data-out performance for space exploration missions.

Main Methods:

Developed a Microfluidic Organic Analyzer (MOA) integrating a Programmable Microfluidic Analyzer (PMA) with a capillary electrophoresis (CE) wafer.
Organic analytes are labeled with fluorescent dyes, separated by CE, and detected using laser-induced fluorescence (LIF) with picomolar limit of detection (LOD).
A technology development unit (TDU) was designed, fabricated, and operated, weighing 3 kg and occupying <5 L.

Main Results:

Achieved a resolution of 2 × 10^5 theoretical plates for amino acids using a 15 cm CE channel.
Demonstrated a LIF limit of detection surpassing 100 pM (0.01 ppb), suitable for biosignature detection.
The MOA TDU meets design goals for a sensitive, automated, and flight-capable instrument.

Conclusions:

The MOA instrument is a viable technology for sensitive, automated organic analysis in harsh extraterrestrial environments.
MOA is well-suited for probing biosignatures on icy moons like Europa and Enceladus, and on Mars.
This technology advances the search for extraterrestrial life and potentially habitable regions within our solar system.