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Raman Spectroscopy Instrumentation: Overview

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Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates

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Published on: March 20, 2015

Photonic-plasmonic resonator for SERS biodetection.

Zheng Tian¹, Zhonghai Zhang¹

¹Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200241, China. zhzhang@chem.ecnu.edu.cn.

|April 16, 2024

Summary

Researchers developed a novel hybrid photonic-plasmonic resonator for surface-enhanced Raman spectroscopy (SERS). This advanced substrate significantly boosts detection sensitivity and minimizes photodamage, enabling precise bioanalysis and cancer diagnosis.

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Area of Science:

Nanophotonics
Plasmonics
Spectroscopy

Background:

Surface-enhanced Raman spectroscopy (SERS) faces challenges with low laser utilization efficiency and substrate photodamage.
Inefficient light-matter interaction in current SERS substrates limits Raman enhancement.
Developing substrates with enhanced optical manipulation is crucial for sensitive SERS detection.

Purpose of the Study:

To create a novel hybrid photonic-plasmonic resonator for improved SERS performance.
To enhance light trapping and localization for increased Raman signal.
To enable sensitive detection of biomolecules and differentiation of cancers while minimizing photodamage.

Main Methods:

Sputtering plasmonic gold nanoparticles (Au NPs) onto photonic titanium dioxide (TiO2) nanocavities.
Tuning Au NP size to match the nanocavity resonance wavelength for maximized light trapping.
Utilizing synergistic electromagnetic and chemical enhancement mechanisms for SERS.

Main Results:

Achieved a SERS enhancement factor of up to 1.75 × 10^9 under non-resonant excitation.
Demonstrated strong absorption and localization of long wavelengths, enabling high SERS enhancement with low light intensity.
Successfully detected various biomolecules, including serum biomarkers, for cancer differentiation.

Conclusions:

The hybrid photonic-plasmonic resonator offers a powerful and sensitive platform for SERS.
This technology effectively minimizes photodamage, crucial for delicate biological samples.
The substrate facilitates advanced bioanalysis and disease diagnosis in complex biological systems.