Related Experiment Video
Updated: Jun 28, 2025
Thermal Ablation for the Treatment of Abdominal Tumors
Published on: March 7, 2011
Ablation of Kidney Tumors in Patients with Substantial Kidney Impairment: Current Status
Toshihiro Iguchi1,2, Yusuke Matsui3, Koji Tomita4
1Department of Radiological Technology, Faculty of Health Sciences, Okayama University, 2-5-1 Shikata-Cho Kita-Ku, Okayama, 700-8558, Japan. iguchi@s.okayama-u.ac.jp.
Purpose Of Review:
To review the current status of kidney tumor ablation in patients with substantial kidney impairment.
Recent Findings:
Few reports of kidney tumor ablation in such patients have recently been published. The reported prevalence of patients with stage 4 or 5 chronic kidney disease (CKD) among patients undergoing ablation is 2.0%-10%. In patients with stage 4 or 5 CKD, local tumor control rates were 88%-100%. The effect of ablation on CKD stage is unclear, and the observed deteriorations in kidney function are consistent with both the effect of cryoablation and the natural course of advanced CKD. According to guidelines, active surveillance may be selected. The goals of treatment are complete tumor removal and maintenance of kidney function, both of which can be met by ablation. Given the limited treatment options, ablation may play a pivotal role in the management of patients with advanced CKD.
Insights
Kidney tumor ablation shows high local control rates (88%-100%) in patients with advanced chronic kidney disease (CKD). While effects on CKD progression are unclear, ablation offers a viable treatment option for these patients.
Area of Science:
- Nephrology
- Oncology
- Interventional Radiology
Background:
- Patients with advanced chronic kidney disease (CKD) often have limited treatment options for kidney tumors.
- Kidney tumor ablation is a minimally invasive technique with potential benefits for organ preservation.
Purpose of the Study:
- To review the current status and outcomes of kidney tumor ablation in patients with significant kidney impairment, specifically stage 4 or 5 CKD.
Main Methods:
- Literature review of recently published reports on kidney tumor ablation in patients with CKD.
- Analysis of local tumor control rates and impact on kidney function.
Main Results:
- Prevalence of stage 4-5 CKD patients undergoing ablation ranges from 2.0% to 10%.
- Local tumor control rates in these patients are high, between 88% and 100%.
- The impact of ablation on CKD progression remains unclear, with observed kidney function changes possibly related to the procedure or natural disease course.
Conclusions:
- Kidney tumor ablation can achieve complete tumor removal while potentially preserving kidney function in patients with advanced CKD.
- Despite uncertainties regarding CKD progression, ablation represents a crucial treatment option given limited alternatives.
- Active surveillance is also a guideline-recommended option for these patients.
Related Concept Videos
01:17Factors Affecting Renal Clearance: Renal Impairment
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
01:11Renal Failure: Dose Adjustments
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...