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Causal effect between gut microbiota and gastroesophageal reflux disease: a bidirectional two-sample Mendelian
Jingyu Liu1, Tongxin Zhang, Xiao Liu
1Department of Ultrasound, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, People's Republic of China.
European Journal of Gastroenterology & Hepatology
|April 16, 2024
Summary
This study used Mendelian randomization to investigate the gut microbiota
Area of Science:
- Microbiome research
- Gastroenterology
- Genetic epidemiology
Background:
- Observational studies suggest a link between gut microbiota and gastroesophageal reflux disease (GERD) pathogenesis.
- The precise causal relationship between gut microbiota and GERD remains unclear.
- Understanding this relationship is crucial for developing targeted interventions.
Purpose of the Study:
- To elucidate the causal effect of gut microbiota on GERD.
- To explore the potential bidirectional relationship between gut microbiota and GERD.
- To identify specific gut microbial taxa influencing GERD risk.
Main Methods:
- A bidirectional two-sample Mendelian randomization analysis was employed.
- Utilized large-scale genome-wide association study (GWAS) data for gut microbiota (MiBioGen alliance) and GERD.
- Applied various statistical methods including Inverse Variance Weighted (IVW), Mendelian randomization Egger, and weighted median.
Main Results:
- The gut bacterium Anaerostipes was found to be causally associated with an increased risk of GERD.
- Eight gut microbial taxa were predicted to causally suppress GERD risk.
- Reverse Mendelian randomization indicated that GERD affects the abundance of 15 gut microbial taxa.
Conclusions:
- A complex causal interplay exists between gut microbiota composition and GERD.
- Findings provide insights for selecting specific probiotics for GERD management.
- This research guides potential microbiome-targeted clinical interventions for GERD.
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