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Updated: Jun 28, 2025
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Published on: November 22, 2016
Origin of the Conformational Stability of Dirhodium(II) Tetrakis[N-phthaloyl-(S)-tert-leucinate] and Its Halogenated
Nobuyuki Hayashi1, Tomomi Ujihara1, Masahiro Anada2
1Institute of Food Research, National Agriculture and Food Research Organization (NARO), 2-1-12 Kannondai, Tsukuba, Ibaraki 305-8642, Japan.
Abstract:
In order to elucidate the origins of the stable structures of dirhodium(II) tetrakis[N-phthaloyl-(S)-tert-leucinate] and the four derivatives with halogenated aromatic rings, the conformational stability and intramolecular interactions were investigated by DFT calculations. In all of these complexes, the conformation in which all ligands face in the same direction is the most stable. When adjacent ligands are in the same orientation, destabilization due to exchange repulsion is larger than that when they are in opposite orientations. However, this destabilizing effect is reversed by the sum of the stabilizing effects of the electronic and charge transfer interactions. The imide carbonyl group plays an important role in these stabilizing interactions. The negatively charged site and bond orbitals in the imide carbonyl group interact with the positively charged sites and bond orbitals in the aromatic ring, the carboxylate group, and the α-position of the carboxylate group in the adjacent ligands. In addition, the lone-pair orbitals of the halogen atoms contribute to conformational stabilization by interacting with the vacant orbitals in the adjacent ligands. However, the combinations of these charged sites or bond orbitals, which effectively contribute to the stabilization, are different for each complex.
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