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The Role of Vascular Endothelial Dysfunction in Hypertension With Hearing Loss

Yinjing Hou1, Bo Liu2

  • 1Department of Geriatrics, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

Angiology
|April 16, 2024
PubMed

Insights

Hypertension can lead to hearing loss, with vascular endothelial dysfunction playing a key role. Biomarkers like endothelin-1 and von Willebrand factor were elevated in hypertensive patients with hearing loss.

Area of Science:

  • Cardiovascular Medicine
  • Otolaryngology
  • Vascular Biology

Background:

  • Hypertension is a known risk factor for hearing loss.
  • The precise mechanisms linking hypertension and hearing loss remain unclear.
  • Vascular endothelial dysfunction is implicated in cardiovascular diseases.

Purpose of the Study:

  • To investigate the role of vascular endothelial dysfunction in hypertensive patients with hearing loss.
  • To identify potential biomarkers associated with hearing loss in hypertension.
  • To assess the diagnostic value of endothelial function tests and biomarkers.

Main Methods:

  • A cohort of 216 hypertensive patients was divided into groups with and without hearing loss.
  • Pure tone audiometry (PTA) was used to assess hearing.
  • Endothelial function was evaluated using reactive hyperemia index (RHI), endothelin-1 (ET-1), and von Willebrand factor (vWF).

Main Results:

  • Patients with hypertension and hearing loss showed significantly higher levels of ET-1 and vWF (P < .05).
  • RHI, ET-1, and vWF were identified as factors associated with hearing loss.
  • The area under the ROC curve (AUC) indicated diagnostic potential for RHI (.652), ET-1 (.706), and vWF (.617).

Conclusions:

  • Vascular endothelial dysfunction appears to contribute to the development of hearing loss in hypertensive individuals.
  • ET-1 and vWF may serve as potential biomarkers for identifying hypertension-related hearing loss.
  • Further research is warranted to elucidate the specific pathways involved.

Keywords:
hearing losshypertensionvascular endothelial function

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