Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

7.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.6K
Tumor Immunotherapy01:27

Tumor Immunotherapy

522
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
522
Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

86
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
86

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The timing of visual selective attention in fronto-parietal network: TMS behavioral and brain structural evidence.

Neuroscience·2026
Same author

Dysregulated sphingolipid metabolismdrives pancreatic carcinogenesis through plasma membrane Kras enrichment.

Gut·2026
Same author

RIG-I-targeted immunotherapy synergizes with immune checkpoint inhibition in a hepatocellular carcinoma model.

Molecular cancer therapeutics·2026
Same author

Lactate-Primed NETosis Modulates Hepatic Regeneration During Acute Liver Failure via the TLR9/KLF15/AJUBA Axis.

Cell proliferation·2026
Same author

Nivolumab in combination with lenvatinib in unresectable hepatocellular carcinoma: The IKF-t006/IMMUNIB translational phase-2 study.

European journal of cancer (Oxford, England : 1990)·2026
Same author

Real-world data on the clinical impact of molecular tumor boards in high- and low-grade serous ovarian cancer.

Frontiers in oncology·2026

Related Experiment Video

Updated: Jun 28, 2025

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy
08:54

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy

Published on: May 8, 2018

14.2K

Unresectable biliary tract cancer: Current and future systemic therapy.

Danmei Zhang1, Klara Dorman1, C Benedikt Westphalen1

  • 1Department of Medicine III, LMU University Hospital, LMU Munich and Comprehensive Cancer Center Munich, Marchioninistr. 15, 81377 Munich, Germany.

European Journal of Cancer (Oxford, England : 1990)
|April 16, 2024
PubMed
Summary

Advanced biliary tract cancer (BTC) treatment now includes immunotherapy and targeted therapies beyond chemotherapy. Genomic assessment is crucial for personalized treatment of unresectable BTC.

Keywords:
Advanced diseaseBiliary tract cancerCholangiocarcinomaEpidemiologyImmunotherapyLoco-regional therapiesMolecular diagnosticReviewTargeted treatment

More Related Videos

Endoscopic Ultrasound-Guided Biliary Drainage: Endoscopic Ultrasound-Guided Hepaticogastrostomy in Malignant Biliary Obstruction
07:44

Endoscopic Ultrasound-Guided Biliary Drainage: Endoscopic Ultrasound-Guided Hepaticogastrostomy in Malignant Biliary Obstruction

Published on: March 25, 2022

5.8K
Complete Laparoscopic Radical Resection of Perihilar Cholangiocarcinoma Type IIIb
04:50

Complete Laparoscopic Radical Resection of Perihilar Cholangiocarcinoma Type IIIb

Published on: January 17, 2025

208

Related Experiment Videos

Last Updated: Jun 28, 2025

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy
08:54

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy

Published on: May 8, 2018

14.2K
Endoscopic Ultrasound-Guided Biliary Drainage: Endoscopic Ultrasound-Guided Hepaticogastrostomy in Malignant Biliary Obstruction
07:44

Endoscopic Ultrasound-Guided Biliary Drainage: Endoscopic Ultrasound-Guided Hepaticogastrostomy in Malignant Biliary Obstruction

Published on: March 25, 2022

5.8K
Complete Laparoscopic Radical Resection of Perihilar Cholangiocarcinoma Type IIIb
04:50

Complete Laparoscopic Radical Resection of Perihilar Cholangiocarcinoma Type IIIb

Published on: January 17, 2025

208

Area of Science:

  • Oncology
  • Gastroenterology

Background:

  • Historically, chemotherapy was the sole treatment for advanced biliary tract cancer (BTC).
  • Recent advancements have introduced immunotherapy and targeted therapies for unresectable BTC.
  • Personalized oncology is increasingly relevant in gastrointestinal malignancies.

Purpose of the Study:

  • To review current knowledge on unresectable BTC.
  • To focus on epidemiology, anatomical distribution, and systemic treatment strategies.
  • To outline ongoing clinical trials and future therapeutic interventions.

Main Methods:

  • Literature review of current knowledge on unresectable BTC.
  • Summary of systemic treatment strategies, including chemotherapy, immunotherapy, and targeted therapy.
  • Analysis of ongoing clinical trials and future directions.

Main Results:

  • Treatment landscape for unresectable BTC has significantly expanded.
  • Immunotherapy and targeted treatments are now guideline-recommended.
  • Genomic-based pathology assessment is vital for personalized treatment.

Conclusions:

  • The management of unresectable BTC is evolving towards personalized medicine.
  • Comprehensive genomic profiling is essential for optimal therapeutic selection.
  • Future interventions hold promise for improved patient outcomes.