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The involvement of ROS-regulated programmed cell death in hepatocellular carcinoma

Hanchen Cai1, Ziqi Meng2, Fujun Yu3

  • 1The First Afliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang Province, China; The Second School of Medicine, Wenzhou Medical University, Wenzhou, 325000, Zhejiang Province, China.

Critical Reviews in Oncology/Hematology
|April 16, 2024
PubMed

Insights

Reactive oxygen species (ROS) regulate programmed cell death (PCD), influencing cancer development. Understanding ROS-induced PCD in hepatocellular carcinoma (HCC) is key for new treatments.

Area of Science:

  • Biochemistry
  • Cell Biology
  • Oncology

Background:

  • Reactive oxygen species (ROS) are vital for cellular functions.
  • Abnormal ROS levels are linked to diseases, especially cancer.
  • Programmed cell death (PCD) pathways like apoptosis, autophagy, and ferroptosis are crucial in disease.
  • ROS-induced PCD plays a significant role in hepatocellular carcinoma (HCC) development.

Purpose of the Study:

  • To review the regulatory role of ROS in PCD.
  • To elucidate how ROS-induced PCD influences tumorigenesis and progression of HCC.
  • To highlight the molecular mechanisms involved in ROS-mediated PCD in HCC.

Main Methods:

  • Literature review of existing research on ROS and PCD in HCC.
  • Analysis of molecular pathways linking ROS, PCD, and cancer.
  • Synthesis of findings to understand the dual role of ROS in cancer progression.

Main Results:

  • ROS act as a double-edged sword, both promoting and inhibiting cancer.
  • A delicate balance of ROS is essential for cellular homeostasis.
  • Disruption of this balance by aberrant ROS generation impacts tumor growth.
  • ROS-induced PCD is a critical factor in HCC pathogenesis.

Conclusions:

  • Understanding ROS-regulated PCD is crucial for HCC prevention and treatment.
  • Targeting ROS-induced PCD pathways may offer novel therapeutic strategies for HCC.
  • Further molecular-level studies can lead to more effective preventative and therapeutic interventions for HCC.
Keywords:
ApoptosisAutophagyFerroptosisHepatocellular carcinomaNecroptosisProgrammed cell deathReactive oxidative species

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