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Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
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  3. Estimation Of The Incidence Of Urachal Cancer: A Systematic Review And Meta-analysis Of Registry-based Studies.
  1. Home
  3. Estimation Of The Incidence Of Urachal Cancer: A Systematic Review And Meta-analysis Of Registry-based Studies.

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Estimation of the incidence of urachal cancer: A systematic review and meta-analysis of registry-based studies.

Csilla Olah1, András Kubik2, Péter Mátrai3

  • 1Department of Urology, University of Duisburg-Essen and German Cancer Consortium (DKTK), Essen, Germany.

Urologic Oncology
|April 16, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

Urachal cancer (UrC) is a rare bladder tumor with low incidence rates and significant geographic variations. This meta-analysis provides updated data on UrC

Keywords:
AdenocarcinomaBladder cancerEpidemiologyIncidenceRegistryUrachal cancerUrachus carcinoma

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Area of Science:

  • Oncology
  • Epidemiology
  • Urologic Oncology

Background:

  • Urachal cancer (UrC) is a rare malignancy, comprising less than 1% of bladder tumors.
  • Limited prospective studies hinder comprehensive understanding of UrC incidence and clinical data.
  • Survival rates for UrC are poor, especially in metastatic cases, highlighting the need for more data.

Purpose of the Study:

  • To conduct a systematic review and meta-analysis of registry-based studies on UrC.
  • To evaluate the incidence and clinicopathological characteristics of unselected UrC patients.
  • To provide an updated overview of UrC epidemiology and survival rates.

Main Methods:

  • Systematic literature search of 5 databases for registry-based UrC studies up to May 2023.
  • Inclusion of 6 selected publications after rigorous review by two independent investigators.
  • Extraction of estimated incidence, clinicopathological parameters, and survival data for meta-analysis.

    • Main Results:

    • Overall UrC incidence rate estimated at 0.04 per 100,000 person-years, with geographic variations (highest in Japan, lowest in Canada).
    • Median age at diagnosis was 60 years, with a female to male ratio of 2:3.
    • Adenocarcinoma was the predominant type (86%), with 5-year survival at 51.0%.

    Conclusions:

    • This meta-analysis offers current, unbiased, registry-based data on UrC incidence, characteristics, and survival.
    • Significant geographic differences in UrC incidence were observed across 6 countries.
    • The findings underscore the rarity of UrC and the need for continued research into this uncommon malignancy.