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An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
06:35

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

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Diagnosis, Treatment, and Follow-Up of Giant-Cell Arteritis: A Retrospective Multicenter Study

Mi-Kyoung Kang1, Yooha Hong1, Yoo Hwan Kim2

  • 1Department of Neurology, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong, Korea.

Journal of Clinical Neurology (Seoul, Korea)
|April 16, 2024
PubMed

Insights

Giant-cell arteritis (GCA) management in Korean patients shows high dropout rates and frequent prednisolone side effects. Optimizing treatment requires regular monitoring and extended follow-up for better outcomes.

Area of Science:

  • Rheumatology
  • Internal Medicine
  • Ophthalmology

Background:

  • Giant-cell arteritis (GCA) is a prevalent vasculitis in the elderly.
  • GCA poses significant risks for visual loss and disease recurrence.
  • Management strategies in Asian populations, particularly Koreans, are less understood due to rarity.

Purpose of the Study:

  • To characterize the current management status of GCA patients in Korea.
  • To analyze treatment patterns, follow-up durations, and outcomes in Korean GCA patients.
  • To evaluate the impact of arteritic anterior ischemic optic neuropathy (AAION) on GCA management.

Main Methods:

  • Retrospective analysis of medical records from six Korean university hospitals (Feb 2009–Nov 2022).
  • Inclusion based on 2022 ACR/EULAR criteria, with original diagnosis by 1990 ACR criteria.
  • Evaluation of treatments, follow-up periods, relapse, remission, and adverse drug reactions.

Main Results:

  • 18 GCA patients analyzed (median age 75.5 years, 66.7% female).
  • Seven patients (38.8%) had AAION; all received initial prednisolone.
  • High dropout rate (72.3%), common adverse events (22.2%), and relapses (11.1%) observed during short follow-ups.

Conclusions:

  • Korean GCA patients exhibit high dropout rates and short follow-up periods.
  • Prednisolone-related adverse effects are common, and relapses occur in approximately 10% of patients.
  • Optimizing GCA treatment necessitates consistent monitoring and long-term patient follow-up.
Abstract

Keywords:
adverse drug reactionblindnessgiant cell arteritisrecurrence

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