Related Experiment Video

Updated: Jun 28, 2025

Extrahepatic Bile Duct and Gall Bladder Dissection in Nine-Day-Old Mouse Neonates
06:10

Extrahepatic Bile Duct and Gall Bladder Dissection in Nine-Day-Old Mouse Neonates

Published on: August 23, 2022

1.9K

Hyaline cartilage at the portal plate and gallbladder in biliary atresia

Sangamitra Rajasekaran1, Hari Neupane1, Monika Bawa2

  • 1Post Graduate Institute of Medical Education and Research (PGIMER), Department of Histopathology, Chandigarh, India.

Autopsy & Case Reports
|April 17, 2024
PubMed

Insights

Biliary atresia (BA) in infants can present with unusual cartilage in resected tissues. This finding suggests a potential metaplastic origin, offering new insights into the disease.

Area of Science:

  • Pediatric Pathology
  • Gastroenterology
  • Developmental Biology

Background:

  • Biliary atresia (BA) is a serious infantile cholestatic liver disease.
  • Early diagnosis and surgical intervention, like Kasai portoenterostomy, are crucial for management.
  • Uncommon histological findings in BA require further investigation.

Observation:

  • A 2-month-old infant with BA exhibited mature and immature hyaline cartilage.
  • Cartilage was identified in the portal plate and gallbladder wall.
  • The infant had previously undergone Kasai portoenterostomy.

Findings:

  • The presence of cartilage in BA resected tissue is rare.
  • Immature cartilage and merging perichondrium suggest a metaplastic process.
  • This finding could indicate a heterotopic or metaplastic etiology in BA.

Implications:

  • Understanding cartilage presence may refine BA etiological theories.
  • This observation could influence diagnostic criteria or treatment strategies.
  • Further research into metaplasia in infantile liver diseases is warranted.

Keywords:
Biliary atresiaGallbladderHyaline cartilageMetaplasiaPortal plate

More Related Videos

A Mouse Model of Chronic Liver Fibrosis for the Study of Biliary Atresia09:12

A Mouse Model of Chronic Liver Fibrosis for the Study of Biliary Atresia

Published on: February 3, 2023

2.4K
Isolation of Neonatal Extrahepatic Cholangiocytes07:54

Isolation of Neonatal Extrahepatic Cholangiocytes

Published on: June 5, 2014

10.3K

Related Concept Videos

Growth of Cartilage and Bone Tissue01:27

Growth of Cartilage and Bone Tissue

Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...
3.2K
Gallbladder01:17

Gallbladder

The gallbladder is a small, pear-shaped organ that plays a crucial role in our digestive system. Measuring about 10 cm in length, it is comparable in size to a kiwi fruit and is located in a hollow area on the lower surface of the liver. The gallbladder's primary function is to store and concentrate bile, a fluid produced by the liver that aids in digestion.
The gallbladder's anatomy consists of three regions: the fundus, body, and neck. Extending from the neck, the cystic duct joins...
511
Liver Histology01:27

Liver Histology

The microscopic anatomy of the liver is a complex and intricate system that comprises numerous structural units known as liver lobules, each of which is comparable in size to a sesame seed. These hexagonal structures consist of plates of liver cells or hepatocytes, which are characterized by their versatility and abundance of cellular apparatus like rough and smooth ER, Golgi apparatus, peroxisomes, and mitochondria.
Hepatocytes perform a variety of essential functions. They secrete...
753
Structural Joints: Cartilaginous Joints01:17

Structural Joints: Cartilaginous Joints

As the name indicates, at a cartilaginous joint, the adjacent bones are united by cartilage, a tough but flexible type of connective tissue. Unlike synovial joints, these types of joints lack a joint cavity and involve bones joined together by either hyaline cartilage or fibrocartilage.
There are two types of cartilaginous joints:
Synchondrosis
A synchondrosis ("joined by cartilage") is a cartilaginous joint where bones are connected by hyaline cartilage. Synchondrosis may be temporary...
2.2K
Gross Anatomy of the Liver01:17

Gross Anatomy of the Liver

The liver, the largest gland within the human body, is a firm and reddish-brown organ. This wedge-shaped structure weighs approximately 1.5 kg and occupies a significant portion of the right hypochondriac and epigastric regions. It extends more to the right of the body's midline than to the left.
Located under the diaphragm, the liver is almost entirely ensconced within the rib cage, providing it with substantial protection. Except for the superior most bare area, the liver's surface is...
419
Development of the Limb Synovial Joints01:07

Development of the Limb Synovial Joints

Joints form during embryonic development in conjunction with the formation and growth of the associated bones. The embryonic tissue that gives rise to all bones, cartilage, and connective tissues of the body is called mesenchyme.
The mesenchymal stem cells differentiate into chondrocytes that form the hyaline cartilage, and later the cartilaginous model of the bone. This model further transforms into a bone. This process is known as endochondral ossification.
During development, the limbs...
1.4K