Analysis of prognostic factors and the role of epilepsy in neurosurgical patients with brain metastases
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View abstract on PubMed
Summary
This summary is machine-generated.Epileptic seizures at onset may indicate silent brain metastases (BMs), improving survival. Identifying prognostic factors like tumor location and single lesions is crucial for tailored treatment strategies in adult BMs patients.
Area Of Science
- Neuro-oncology
- Neurosurgery
- Clinical Neurology
Background
- Brain metastases (BMs) are the most common brain tumors in adults.
- Identifying prognostic factors is key for personalized therapeutic strategies.
- Epilepsy can be an early symptom of BMs.
Purpose Of The Study
- To investigate the impact of epilepsy and other prognostic factors on the survival of patients with brain metastases.
Main Methods
- Retrospective study of 51 patients with BMs who underwent neurosurgery (2010-2021).
- Analysis of brain metastasis features and clinical characteristics using uni- and multivariate analysis.
- Overall survival (OS) was the primary endpoint.
Main Results
- Average OS was 25.98 months, varying by primary tumor histology.
- Primary tumor location, extracranial metastases, and lesion multiplicity significantly impacted OS.
- Single BMs and temporal lobe BMs were associated with superior OS.
- Seizures at onset, good post-operative Karnofsky status, absence of complications, and post-operative treatment correlated with higher OS.
Conclusions
- Clinical onset with seizures can identify previously undetected BMs.
- Favorable prognostic factors include specific tumor characteristics and patient clinical status.
- Early identification via seizures may enable prompt, aggressive multidisciplinary treatment.
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