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Updated: Jun 28, 2025

Meso-Scale Particle Image Velocimetry Studies of Neurovascular Flows In Vitro

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Published on: December 3, 2018

Plastic vasomotion entrainment.

Daichi Sasaki¹, Ken Imai¹, Yoko Ikoma¹

¹Super-network Brain Physiology, Graduate School of Life Sciences, Tohoku University, Sendai, Japan.

|April 17, 2024

Summary

This summary is machine-generated.

Researchers discovered global brain vasomotion synchronization in mice using visual stimuli. This frequency-locked blood vessel activity, quantified via autofluorescence, shows parallel plasticity with neuronal circuits, suggesting enhanced energy delivery for brain function.

Keywords:

brain horizontal optokinetic response hyperemia motor learning mouse neuroscience vasomotion visual stimulation

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Area of Science:

Neuroscience
Physiology
Biophotonics

Background:

Vasomotion, or blood vessel oscillation, plays a crucial role in regulating cerebral blood flow.
Understanding the synchronization and plasticity of vasomotion is key to comprehending brain function and adaptation.

Purpose of the Study:

To investigate the global synchronization of vasomotion induced by oscillating visual stimuli in the mouse brain.
To quantify the magnitude and plasticity of frequency-locked vasomotion using endogenous autofluorescence.
To explore the relationship between vasomotion plasticity and neuronal circuit learning, specifically the horizontal optokinetic response (HOKR).

Main Methods:

Utilized endogenous autofluorescence to quantify vessel 'shadow' and measure frequency-locked vasomotion.
Employed wide-field macro-zoom microscopy and deep-brain fiber photometry in awake, non-transgenic wild-type mice.
Presented horizontally oscillating vertical stripes at 0.25 Hz to induce visual stimulation and measured vasomotion across cortical and cerebellar areas.

Main Results:

Identified global synchronization of vasomotion across wide cortical areas and the cerebellum, locked to the visual stimulus frequency.
Demonstrated that visually induced vasomotion adapts to various stimulation parameters and exhibits plastic entrainment with repeated trials.
Showed a strong correlation between horizontal optokinetic response (HOKR) performance gain and vasomotion entrainment magnitude in the cerebellar flocculus.

Conclusions:

Visually induced vasomotion exhibits plasticity that occurs in parallel with neuronal circuit plasticity.
Entrained vasomotion may enhance energy delivery to support increased coordinated neuronal activity and circuit reorganization.
This study provides a novel method for quantifying vasomotion and reveals its adaptive capabilities in response to sensory input.