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The role of SWI/SNF complexes in digestive system neoplasms

Hanyun Liang1, Xin Zheng1, Xiao Zhang2

  • 1Department of Diagnostic Pathology, Shandong Second Medical University, Weifang, 261053, China.

Medical Oncology (Northwood, London, England)
|April 17, 2024
PubMed

Insights

SWI/SNF chromatin remodeling complexes are crucial in DNA repair and preventing cancer. Mutations in SWI/SNF subunits are common in digestive tumors, offering potential therapeutic targets.

Area of Science:

  • Epigenetics
  • Molecular Biology
  • Cancer Research

Background:

  • Chromatin remodeling is vital for DNA damage response and preventing genomic instability.
  • ATP-dependent chromatin remodelers, like SWI/SNF complexes, regulate gene accessibility and nucleosome assembly.
  • SWI/SNF subunit mutations are frequently observed in digestive system tumors.

Purpose of the Study:

  • To review recent literature on the role of SWI/SNF complexes in digestive tumorigenesis.
  • To explore the diverse functions of different SWI/SNF subunits in cancer development.
  • To identify potential therapeutic strategies targeting SWI/SNF pathways.

Main Methods:

  • Literature review of recent studies on SWI/SNF complexes in digestive cancers.
  • Analysis of the roles of different SWI/SNF subunits in tumor cell behavior and signaling pathways.
  • Investigation of the correlation between SWI/SNF mutations and patient prognosis.

Main Results:

  • Different SWI/SNF subunits exhibit distinct roles in digestive tumorigenesis.
  • SWI/SNF complexes influence tumor cell biology, signaling pathways, and gene interactions.
  • SWI/SNF alterations are correlated with patient prognosis in digestive cancers.

Conclusions:

  • Understanding SWI/SNF complex mutations and functions is key to developing new digestive cancer therapies.
  • Targeting SWI/SNF-related genes or the tumor microenvironment presents promising therapeutic avenues.
  • SWI/SNF complexes represent potential targets for novel digestive cancer treatments.
Keywords:
Chromatin remodeling complexesDigestive system neoplasmsMismatch repairSWI/SNF

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