Association of central nervous system sarcoma with familial polyposis coli

Familial polyposis of the colon is associated with an increased incidence in other parts of the body of benign and malignant, soft and hard connective tissue tumours. Clinical details and autopsy findings are reported in a 35-year-old man with familial polyposis who died from reticulum cell sarcoma (microglioma) involving his brain stem and upper spinal cord. While other central nervous system malignancy has been reported in association with familial polyposis, a sarcomatous tumour has not been previously described. In the clinical assessment of patients with familial polyposis the possibility should be considered of associated tumours in extracolonic sites, including the central nervous system.