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Updated: Jun 28, 2025

Porous Silicon Microparticles for Delivery of siRNA Therapeutics
Published on: January 15, 2015
Recent Progress of Small Interfering RNA Delivery on the Market and Clinical Stage
Fan Guo1,2, Yan Li2,3, Wenjun Yu2,3
1School of Pharmacy, Binzhou Medical University, Shandong 264003, China.
Abstract:
Small interfering RNAs (siRNAs) are promising therapeutic strategies, and five siRNA drugs have been approved by the Food and Drug Administration (FDA) and the European Commission (EC). This marks a significant milestone in the development of siRNA for clinical applications. The approved siRNA agents can effectively deliver siRNAs to the liver and treat liver-related diseases. Currently, researchers have developed diverse delivery platforms for transporting siRNAs to different tissues such as the brain, lung, muscle, and others, and a large number of siRNA drugs are undergoing clinical trials. Here, these delivery technologies and the latest advancements in clinical applications are summarized, and this Review provides a concise overview of the strategies employed for siRNA delivery to both hepatic and extrahepatic tissues.
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