Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Photoreceptors and Visual Pathways01:22

Photoreceptors and Visual Pathways

6.0K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
6.0K
Anatomy of the Eyeball01:20

Anatomy of the Eyeball

7.1K
The eye is a spherical, hollow structure composed of three tissue layers. The outer layer — the fibrous tunic, comprises the sclera — a white structure — and the cornea, which is transparent. The sclera encompasses some of the ocular surface, most of which is not visible. However, the 'white of the eye' is distinctively visible in humans compared to other species. The cornea, a clear covering at the front of the eye, enables light penetration. The eye's middle...
7.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multimodal Imaging of Choroidal Lymphoma: Diagnostic Features, Differential Diagnosis, and Clinical Monitoring.

Ocular immunology and inflammation·2026
Same author

TNF inhibitors for the long-term management of juvenile idiopathic arthritis associated uveitis: real-life data from the ITHACA cohort.

Expert opinion on biological therapy·2026
Same author

Review of emerging imaging findings to reveal a broader spectrum of lesions in AMD.

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie·2026
Same author

Pathways to Patchy Atrophy in High Myopia: Precursor Patterns, Structural Characteristics, and Long-Term Outcomes.

Ophthalmology science·2026
Same author

Unfolding the Pitchfork Sign in Type 2 Choroidal Neovascularization: A Longitudinal Analysis and 3-Dimensional Reconstructions.

Ophthalmology science·2026
Same author

Advanced Multimodal Imaging in Granulomatous Uveitis: From Differential Diagnosis to Treatment Monitoring and Surgical Integration.

Journal of clinical medicine·2026
Same journal

Loss of ATRAID in Late-Onset, Non-Syndromic Retinitis Pigmentosa.

Investigative ophthalmology & visual science·2026
Same journal

Whole-Exome Analysis Identifies Candidate Genes Associated With Diabetic Retinopathy.

Investigative ophthalmology & visual science·2026
Same journal

Antiseptic Efficacy and Ocular Surface Toxicity of Povidone-Iodine and Chlorhexidine for Endophthalmitis Isolates.

Investigative ophthalmology & visual science·2026
Same journal

Ocular IL-1α/IFN-γ Delay the Corneal Wound Healing in Rheumatoid Arthritis Through Mitochondrial Dysfunction and NLRP3 Inflammasome Activation.

Investigative ophthalmology & visual science·2026
Same journal

New Guidelines for Ophthalmic Genetic Studies.

Investigative ophthalmology & visual science·2026
Same journal

Genomic Copy Number Variants Associated With Strabismus and Amblyopia in the All of Us Research Program.

Investigative ophthalmology & visual science·2026
See all related articles

Related Experiment Video

Updated: Jun 28, 2025

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
10:14

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Published on: May 26, 2023

3.1K

Photoreceptor Integrity in MEWDS: Longitudinal Structure-Function Correlations.

Maria Vittoria Cicinelli1,2,3, Giovanni Montesano4,5, Alessandro Berni1,2

  • 1School of Medicine, Vita-Salute San Raffaele University, Milan, Italy.

Investigative Ophthalmology & Visual Science
|April 17, 2024
PubMed
Summary
This summary is machine-generated.

Photoreceptor reflectivity accurately reflects visual function in multiple evanescent white dot syndrome (MEWDS). Recovery shows a central-to-peripheral gradient, possibly indicating disc area vulnerabilities.

More Related Videos

Direct-Coupled Electroretinogram DC-ERG for Recording the Light-Evoked Electrical Responses of the Mouse Retinal Pigment Epithelium
09:10

Direct-Coupled Electroretinogram DC-ERG for Recording the Light-Evoked Electrical Responses of the Mouse Retinal Pigment Epithelium

Published on: July 14, 2020

5.2K
Multifocal Electroretinograms
16:49

Multifocal Electroretinograms

Published on: December 4, 2011

18.3K

Related Experiment Videos

Last Updated: Jun 28, 2025

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
10:14

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Published on: May 26, 2023

3.1K
Direct-Coupled Electroretinogram DC-ERG for Recording the Light-Evoked Electrical Responses of the Mouse Retinal Pigment Epithelium
09:10

Direct-Coupled Electroretinogram DC-ERG for Recording the Light-Evoked Electrical Responses of the Mouse Retinal Pigment Epithelium

Published on: July 14, 2020

5.2K
Multifocal Electroretinograms
16:49

Multifocal Electroretinograms

Published on: December 4, 2011

18.3K

Area of Science:

  • Ophthalmology
  • Retinal Imaging
  • Visual Electrophysiology

Background:

  • Multiple evanescent white dot syndrome (MEWDS) is an inflammatory condition affecting the outer retina.
  • Understanding the relationship between structural changes and visual function is crucial for managing MEWDS.
  • Current imaging techniques like SD-OCT and MP offer insights into retinal integrity and function.

Purpose of the Study:

  • To investigate structure-function correlations in MEWDS.
  • To utilize microperimetry (MP) and spectral-domain optical coherence tomography (SD-OCT) for detailed analysis.
  • To assess the dynamic changes in photoreceptor integrity and visual sensitivity over time.

Main Methods:

  • A prospective observational study involving 14 eyes from 13 MEWDS patients.
  • Evaluated best-corrected visual acuity (BCVA), foveal granularity, and Photoreceptor Reflectivity Ratio (PRR).
  • Assessed retinal threshold sensitivity (RTS) and fixation stability (BCEA) using MP; analyzed data with hierarchical linear mixed models.

Main Results:

  • Photoreceptor Reflectivity Ratio (PRR) showed a transient decrease then progressive increase, indicating photoreceptor disruption and recovery.
  • Eyes with foveal granularity had significantly lower foveal sensitivity and increased fixation spread.
  • Retinal threshold sensitivity (RTS) improved significantly over time with a central-to-peripheral gradient, and improved faster in eyes with worse baseline vision.

Conclusions:

  • Photoreceptor reflectivity is a reliable indicator of visual function in MEWDS patients during follow-up.
  • The observed central-to-peripheral gradient of visual recovery suggests potential vulnerabilities around the optic disc area.
  • These findings enhance our understanding of MEWDS pathophysiology and visual recovery patterns.