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Updated: Jun 28, 2025

An Orthotopic Bladder Cancer Model for Gene Delivery Studies

An Orthotopic Bladder Cancer Model for Gene Delivery Studies

Published on: December 1, 2013

Preclinical models for bladder cancer therapy research.

Iris Ertl¹, Shahrokh F Shariat^{1,2,3,4,5,6,7}, Walter Berger⁸

¹Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.

Current Opinion in Urology

|April 17, 2024

Summary

Recent advancements in bladder cancer (BC) research have yielded preclinical models like patient-derived organoids and xenografts. These models closely mimic tumor biology, aiding in the development of targeted therapies for diverse BC subtypes.

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Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development

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Published on: October 30, 2013

Area of Science:

Oncology
Translational Research
Cancer Biology

Background:

Bladder cancer (BC) is a heterogeneous disease, posing challenges for developing effective treatments.
Preclinical models are crucial for understanding BC subtypes and identifying targeted therapies.

Purpose of the Study:

To review recent progress in developing preclinical models for bladder cancer.
To highlight models that closely mimic the in vivo characteristics of diverse BC tumors.

Main Methods:

Focus on patient-derived organoids (PDOs) and patient-derived xenografts (PDXs).
Evaluation of syngenic in vivo models in immunocompetent hosts.

Main Results:

PDOs and PDXs effectively recapitulate molecular, histopathological, and drug response profiles of original tumors.
Syngenic models are valuable for developing immunotherapeutics and studying immune system interactions.

Conclusions:

New in vitro and in vivo models have been developed in the past two years.
These models closely replicate the biology and heterogeneity of human bladder tumors, supporting drug development and personalized medicine.