Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Expression sequences of cell adhesion molecules.

K L Crossin, C M Chuong, G M Edelman

    Proceedings of the National Academy of Sciences of the United States of America
    |October 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The Molecular Circuit Regulating Tooth Development in Crocodilians.

    Journal of dental research·2016
    Same author

    Topology of feather melanocyte progenitor niche allows complex pigment patterns to emerge.

    Science (New York, N.Y.)·2013
    Same author

    Complexity and coherency: integrating information in the brain.

    Trends in cognitive sciences·2011
    Same author

    Modulation of expression and cell surface distribution of N-CAM during myogenesis in vitro.

    Neurochemistry international·2010
    Same author

    What is the biological basis of pattern formation of skin lesions?

    Experimental dermatology·2006
    Same author

    Differential translation and fragile X syndrome.

    Genes, brain, and behavior·2005
    Same journal

    In This Issue.

    Proceedings of the National Academy of Sciences of the United States of America·2026
    Same journal

    Long-term cultural continuity across the Neanderthal-modern human sequence at Üçağızlı II Cave, northern Levant.

    Proceedings of the National Academy of Sciences of the United States of America·2026
    Same journal

    Dolphins use names to remember whom to avoid.

    Proceedings of the National Academy of Sciences of the United States of America·2026
    Same journal

    Retraction for Shaked and Frenkel, Curiouser and curiouser: Meningeal lymphoid structures in the aging brain.

    Proceedings of the National Academy of Sciences of the United States of America·2026
    Same journal

    Small but mighty: The outsized role of small water bodies in the global carbon cycle.

    Proceedings of the National Academy of Sciences of the United States of America·2026
    Same journal

    Functional traits produce conditional outcomes in different community contexts.

    Proceedings of the National Academy of Sciences of the United States of America·2026
    See all related articles

    Neural CAM (N-CAM) and Liver CAM (L-CAM) expression in chicken embryos reveals transient patterns across germ layers during development. These cell adhesion molecules play key roles in embryonic induction sites.

    Area of Science:

    • Developmental Biology
    • Cell Biology
    • Immunocytochemistry

    Background:

    • Cell adhesion molecules (CAMs) are crucial for tissue development and organization.
    • Previous studies established a sequence of CAM expression during chicken embryogenesis.
    • More sensitive techniques allow for a reexamination of CAM expression patterns.

    Purpose of the Study:

    • To reexamine the expression patterns of cell adhesion molecules (CAMs) in chicken embryo development using advanced immunocytochemical methods.
    • To identify novel sites and temporal dynamics of neural CAM (N-CAM) and liver CAM (L-CAM) expression.
    • To characterize the role of CAMs in embryonic induction sites.

    Main Methods:

    • Utilized highly sensitive immunocytochemical techniques for detailed analysis of CAM expression.

    Related Experiment Videos

  • Examined CAM distribution across various tissues and germ layers of the developing chicken embryo.
  • Investigated CAM expression at sites of embryonic induction, observing interactions between epithelial and mesenchymal cells.

    • Main Results:

    • Confirmed previously established CAM expression sequences.
    • Detected N-CAM on endodermal (lung, gut, pancreas) and ectodermal derivatives, often transiently.
    • Observed co-expression of N-CAM and L-CAM at embryonic induction sites, with distinct modulation patterns (Mode I and Mode II) in apposed cell collectives.

    Conclusions:

    • N-CAM and L-CAM are expressed on derivatives of all three germ layers during chicken embryonic development.
    • Specific modulation patterns of N-CAM and L-CAM at induction sites suggest their critical role in mediating cell interactions.
    • The findings provide new insights into the dynamic regulation of cell adhesion during fundamental developmental processes.