Efficacy and safety of topical 0.5% 5-Fluorouracil as primary treatment of ocular surface squamous neoplasia
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Summary
This summary is machine-generated.Topical 0.5% 5-Fluorouracil (5-FU) effectively treats ocular surface squamous neoplasia (OSSN), achieving complete resolution in most patients. This primary therapy demonstrated a low side effect profile, making it a safe option for OSSN management.
Area Of Science
- Ophthalmology
- Oncology
- Dermatology
Background
- Ocular surface squamous neoplasia (OSSN) is a premalignant lesion of the conjunctiva and cornea.
- Current treatment options for OSSN include surgical excision, topical chemotherapy, and immunotherapy.
- There is a need for effective and safe primary non-surgical therapies for OSSN.
Purpose Of The Study
- To evaluate the efficacy and safety of topical 0.5% 5-Fluorouracil (5-FU) as a primary treatment for OSSN.
- To determine the complete resolution rate, recurrence rate, and adverse effects associated with topical 5-FU therapy for OSSN.
Main Methods
- Retrospective study of 54 patients diagnosed with OSSN.
- Topical 0.5% 5-FU applied four times daily for two weeks, followed by a two-week break, in cycles.
- Diagnostic confirmation via exfoliative cytology.
Main Results
- Complete resolution of OSSN was achieved in 70.4% of patients.
- The most common side effects were eyelid erythema, conjunctival hyperemia, and punctal stenosis (35.2%), with no treatment discontinuation.
- The overall recurrence rate was 14.8%, and complete response to 5-FU significantly reduced relapse risk (84% lower).
Conclusions
- Topical 0.5% 5-FU can be considered a safe and effective primary therapy for OSSN.
- The treatment shows a favorable safety profile with manageable side effects.
- Further research may explore optimizing 5-FU protocols for OSSN management.
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