Related Experiment Video
Updated: Jun 28, 2025

Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research
Published on: November 3, 2023
Impact of Coronavirus Disease 2019 Pandemic on Cardiac Arrest and Emergency Care
Murtaza Bharmal1, Kyle DiGrande1, Akash Patel1
1Department of Cardiology, University of California Irvine Medical Center, 510 E Peltason Drive, Irvine, CA 92697, USA.
The coronavirus disease 2019 (COVID-19) pandemic led to more cardiac arrests and worse patient outcomes. Understanding these pandemic-related factors is crucial for improving future emergency medical responses and saving lives.
Area of Science:
- Emergency Medicine
- Public Health
- Epidemiology
Background:
- The COVID-19 pandemic has significantly impacted healthcare systems globally.
- Cardiac arrest incidence and outcomes are critical indicators of healthcare system stress and public health.
- Previous research has not fully elucidated the pandemic's specific effects on cardiac arrest events.
Purpose of the Study:
- To analyze the incidence and outcomes of out-of-hospital cardiac arrest (OHCA) and in-hospital cardiac arrest (IHCA) during the COVID-19 pandemic.
- To identify factors contributing to changes in cardiac arrest events and patient survival.
- To inform strategies for mitigating the impact of future pandemics on cardiovascular emergencies.
Main Methods:
- Retrospective analysis of cardiac arrest data.
- Comparison of cardiac arrest incidence and survival rates before and during the COVID-19 pandemic.
- Multivariate analysis to identify factors associated with changes in outcomes.
Main Results:
- A notable increase in both OHCA and IHCA incidence was observed during the pandemic.
- Patient survival rates and neurologic outcomes following cardiac arrest significantly decreased.
- Both direct viral effects and indirect pandemic-related factors (e.g., healthcare system strain, behavioral changes) were implicated.
Conclusions:
- The COVID-19 pandemic adversely affected cardiac arrest incidence and patient survival.
- Interventions addressing both direct illness and indirect systemic effects are necessary.
- Improved preparedness for future public health crises is essential to protect patients experiencing cardiac arrest.
Related Concept Videos
Exercise and Cardiovascular Response
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Disturbances in Heart Rhythm
Arrhythmias are categorized by their speed, rhythm, and origin. A slow...
Imbalances in Cardiac Output
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
Pathophysiology of Cardiac Performance
Decreased pulse rate
There are specific risk factors that can elevate the likelihood of developing bradycardia. Advanced age is a significant factor, with...
Ischemic Heart Disease: Overview
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...

