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Related Concept Videos

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Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
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Related Experiment Video

Updated: Jun 17, 2026

Technique and Patient Selection Criteria of Right Anterior Mini-Thoracotomy for Minimal Access Aortic Valve Replacement
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Technique and Patient Selection Criteria of Right Anterior Mini-Thoracotomy for Minimal Access Aortic Valve Replacement

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Patient-specific ascending aortic intervention criteria.

Paris D Kalogerakos1, Mohammad A Zafar1, Yupeng Li2

  • 1Department of Surgery, Division of Cardiac Surgery, Aortic Institute at Yale-New Haven Hospital, Yale University School of Medicine, New Haven, CT, USA.

European Journal of Cardio-Thoracic Surgery : Official Journal of the European Association for Cardio-Thoracic Surgery
|April 17, 2024
PubMed
Summary

Personalized risk stratification for ascending aortic aneurysms is now possible. New risk curves, based on patient demographics and aneurysm size, identify individuals at higher risk for adverse events.

Keywords:
Ascending aortic aneurysmCalculatorPatient specificRisk predictionSurgical thresholdz score

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Area of Science:

  • Cardiovascular Medicine
  • Medical Statistics
  • Aortic Disease Research

Background:

  • Ascending aortic aneurysms present variable risks to patients.
  • Current risk stratification may not be sufficiently personalized.

Purpose of the Study:

  • To develop personalized risk stratification for ascending aortic aneurysms.
  • To identify risk based on sex, age, body surface area, and aneurysm location.

Main Methods:

  • Analyzed diameters and adverse events in 1162 ascending thoracic aortic aneurysm patients.
  • Converted aortic diameters to z-scores relative to population norms.
  • Correlated z-scores with adverse events to create risk curves for root and ascending aorta.

Main Results:

  • Established generalized risk thresholds: z=4 for aortic root, z=5 for mid-ascending aorta.
  • Individualized thresholds are often below the standard 5.5 cm criterion.
  • An automated calculator is available for high-risk patient identification.

Conclusions:

  • This study provides tailored risk thresholds for ascending aortic aneurysms.
  • Utilizes a large patient cohort, population demographics, and statistical analysis.
  • Enables personalized risk assessment for improved patient management.