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Purification and Aggregation of the Amyloid Precursor Protein Intracellular Domain
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Published on: August 28, 2012

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Pathway for Development and Validation of Multi-domain Endpoints for Amyloid Light Chain (AL) Amyloidosis

James Signorovitch1, Jialu Zhang2, David Brown3

  • 1Analysis Group, Boston, USA.

Therapeutic Innovation & Regulatory Science
|April 17, 2024
PubMed
Summary

Developing multi-domain endpoints (MDEs) for immunoglobulin light chain (AL) amyloidosis is crucial for advancing new therapies. This initiative aims to create validated endpoints for clinical trials in this rare, multi-system disease.

Keywords:
AL amyloidosisClinical trialMulti-domain endpointsPublic–private partnershipRare diseasesStatistical validation

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