Related Experiment Video
Updated: Jun 28, 2025
09:36
Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device
Published on: September 24, 2020
2.8K
Risk factors for progressing to critical illness in patients with hospital-acquired COVID-19
Kyung-Eui Lee1, Jinwoo Lee2, Sang-Min Lee1,2
1Department of Critical Care Medicine, Seoul National University Hospital, Seoul, Korea.
The Korean Journal of Internal Medicine
|April 18, 2024
Summary
Hospital-acquired COVID-19 patients with respiratory or cardiovascular disease, immunocompromised status, or frailty are at higher risk for critical illness. Early identification and isolation are crucial for better outcomes.
Area of Science:
- Infectious Diseases
- Critical Care Medicine
- Epidemiology
Background:
- Risk factors for progression to critical illness in hospital-acquired coronavirus disease 2019 (COVID-19) were previously unknown.
- This study aimed to identify these risk factors and their impact on clinical outcomes.
Purpose of the Study:
- To assess the incidence and risk factors for progression to critical illness in hospital-acquired COVID-19.
- To determine the effects of these risk factors on clinical outcomes.
Main Methods:
- A retrospective cohort study of 204 patients with hospital-acquired COVID-19 admitted between January 2020 and June 2022.
- Patients were stratified into risk groups based on identified risk factors.
- Multivariable logistic regression was used to analyze risk factors for progression to critical illness.
Main Results:
- 18.1% of patients (37 out of 204) progressed to critical illness.
- Preexisting respiratory disease, cardiovascular disease, immunocompromised status, higher Sequential Organ Failure Assessment (SOFA) score, and higher Clinical Frailty Scale were significant risk factors.
- Increased risk group stratification correlated with higher progression to critical illness and 28-day mortality.
Conclusions:
- Preexisting respiratory disease, cardiovascular disease, immunocompromised status, and higher SOFA and Clinical Frailty Scale scores are key risk factors for critical illness in hospital-acquired COVID-19.
- Prioritizing and isolating patients with these risk factors is essential for timely treatment and improved outcomes, particularly during pandemics.
Related Concept Videos
01:30Pneumonia I: Introduction
230
Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
230
01:30Pneumonia III: Complications and Assessment
205
Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
205
01:26Factors Affecting the Risk of Infection
11.8K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
11.8K
01:25Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
2.7K
Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
2.7K
01:30Acute Respiratory Failure-III
184
Hypercapnic respiratory failure, also known as Type 2 or ventilatory respiratory failure, is a severe condition characterized by the body's inability to effectively remove carbon dioxide (CO2) from the bloodstream. It leads to an arterial CO2 pressure (PaCO2) exceeding 45 mmHg and a blood pH above 7.35. This situation indicates that the body's ventilatory demand, or the ventilation needed to maintain normal PaCO2 levels, surpasses its supply or the maximum gas flow achievable without...
184
01:29Acute Respiratory Failure-V
136
The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
Ensure that patients are monitored continuously for their response to therapy, including changes in...
Ensure that patients are monitored continuously for their response to therapy, including changes in...
136