Related Experiment Video
Updated: Jun 28, 2025
Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice
Published on: February 22, 2019
The Impact of Vaccination Among Hospitalized Patients with the Diagnosis of COVID-19
Yeşim Yıldız1, Hasan Selçuk Özger1, Ali Acar2
1Department of Infectious Disease and Clinical Microbiology, Gazi University School of Medicine, Ankara, Turkey.
Insights
Fully vaccinated patients with breakthrough COVID-19 infections had a significantly lower need for intensive care unit (ICU) support. Risk factors for ICU admission included older age, hypertension, diabetes mellitus, and congestive heart failure.
Area of Science:
- Infectious Diseases
- Vaccinology
- Critical Care Medicine
Background:
- Breakthrough infections of COVID-19 in vaccinated individuals necessitate understanding risk factors for severe outcomes.
- Intensive care unit (ICU) support is a critical indicator of disease severity.
Purpose of the Study:
- To investigate the vaccination status of hospitalized patients with laboratory-confirmed COVID-19 breakthrough infections.
- To identify risk factors associated with the need for ICU support in these patients.
Main Methods:
- A multi-center point-prevalence study involving 516 hospitalized patients.
- Patients were categorized into 'fully' and 'partially' vaccinated groups.
- Comparison of demographic data, comorbidities, and ICU admission rates between vaccinated and unvaccinated groups.
Main Results:
- Older age, hypertension, diabetes mellitus (DM), and congestive heart failure (CHF) were significantly associated with higher ICU admission rates.
- Fully vaccinated patients (16.9%) demonstrated a statistically significant lower need for ICU support (p=0.021).
- Hypertension, DM, and CHF were more prevalent in the ICU patient group.
Conclusions:
- Older age, specific comorbidities (hypertension, DM, CHF), and partial vaccination are linked to increased ICU support needs following COVID-19 breakthrough infection.
- Continuous monitoring of post-vaccination infections is crucial for informing national booster vaccine strategies.
- Ensuring vulnerable populations receive optimal protection through timely vaccination and boosters is paramount.
Objective:
We aimed to investigate the vaccination status and the risk factors for the intensive care unit (ICU) support need of the laboratory-confirmed breakthrough COVID-19 infection inpatients.
Materials And Methods:
This multi-center point-prevalence study was conducted on inpatients, divided into two groups as 'fully' and 'partially' vaccinated according to COVID-19 vaccination status.
Results:
Totally 516 patients were included in the study. The median age was 65 (55-77), and 53.5% (n=276) of the patients were male. Hypertension (41.9%, n=216), diabetes mellitus (DM) (31.8%, n=164), and coronary artery disease (CAD) (16.3%, n=84) were the predominant comorbidities. Patients were divided into two groups ICU (n=196) and non-ICU (n=301). Hypertension (p=0.026), DM (p=0.048), and congestive heart failure (CHF) (p=0.005) were significantly higher in ICU patients and the median age was younger among non-ICU patients (p=0.033). Of patients, 16.9% (n=87) were fully vaccinated, and this group's need for ICU support was statistically significantly lower (p=0.021).
Conclusion:
We conclude that older age, hypertension, DM, CHF, and being partially vaccinated were associated with the need for ICU support. Therefore, all countries should continuously monitor post-vaccination breakthrough COVID-19 infections to determine the national booster vaccine administration approach that will provide vulnerable individuals the highest protection.
More Related Videos
11:32Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria
Published on: February 23, 2014
12:21A Mouse Model for the Transition of Streptococcus pneumoniae from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness
Published on: September 28, 2022
Related Concept Videos
01:51Vaccinations
01:28Pneumonia IV: Management
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
01:22Healthcare Associated Infections II: Preventive Measures
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
01:26Factors Affecting the Risk of Infection
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
01:30Pneumonia III: Complications and Assessment
01:25Transmission-based Precautions II: Airborne and Protective Environment
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...