Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Retrovirus Life Cycles01:10

Retrovirus Life Cycles

45.9K
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
45.9K
Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

179
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
179
Transmission-based Precautions II: Airborne and Protective Environment01:25

Transmission-based Precautions II: Airborne and Protective Environment

1.2K
Transmission-based precautions are for patients infected or suspected to be infected (or colonized) with organisms posing a significant risk to others. The transmission precautions include airborne and protective environment precautions.
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
1.2K
Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

4.7K
The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
4.7K
The Electron Transport Chain01:30

The Electron Transport Chain

16.7K
The electron transport chain or oxidative phosphorylation is an exothermic process in which free energy released during electron transfer reactions is coupled to ATP synthesis. This process is a significant source of energy in aerobic cells, and therefore inhibitors of the electron transport chain can be detrimental to the cell's metabolic processes.
Inhibitors of the electron transport chain
Rotenone, a widely used pesticide, prevents electron transfer from Fe-S cluster to ubiquinone or Q...
16.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Innate immunogenetic synergy between KIR and Neanderthal-derived OAS variants predicts COVID-19 outcomes.

PloS one·2026
Same author

Design, Synthesis and Molecular Modeling Studies of Triazole Derivatives as Aromatase İnhibitors.

Chemical biology & drug design·2026
Same author

Clinical Course and Risk Factors Affecting Mortality in Patients with Solid Organ Malignancies and COVID-19 Infection: A Retrospective Case-Control Study.

Infectious diseases & clinical microbiology·2026
Same author

Impact of Advanced Age on Posttransplant Infections and Outcomes in Solid Organ Transplant Recipients: A Multicenter Cohort Study.

Transplant infectious disease : an official journal of the Transplantation Society·2026
Same author

Design and Synthesis of Bis-Triazole-Linked Benzenesulfonamides as Selective Carbonic Anhydrase IX/XII Inhibitors with Chemosensitizing Activity.

Journal of medicinal chemistry·2026
Same author

Evaluation of Latent Tuberculosis Infection Risk in Liver Transplant Recipients.

Journal of clinical medicine·2026

Related Experiment Video

Updated: Jun 28, 2025

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
08:41

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

Published on: November 5, 2021

2.7K

SARS-CoV-2 Infection may be Prevented with Cytochrome Inhibitors: Cobicistat and Ritonavir.

İsmail Çelik1, Ezgi Gülten2, Arzu Onay-Beşikci3

  • 1Department of Pharmaceutical Chemistry, Erciyes University School of Pharmacy, Erciyes University, Kütahya, Turkey.

Infectious Diseases & Clinical Microbiology
|April 18, 2024
PubMed
Summary

Cobicistat and ritonavir, cytochrome P450 inhibitors, show strong interactions with key SARS-CoV-2 proteins, suggesting their potential for preventing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. These findings offer new therapeutic avenues for COVID-19 prevention.

Keywords:
SARS-CoV-2antiretroviral therapycobicistatritonavir

More Related Videos

Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors
10:29

Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors

Published on: May 9, 2025

998
Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds
09:29

Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds

Published on: October 29, 2015

30.2K

Related Experiment Videos

Last Updated: Jun 28, 2025

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
08:41

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

Published on: November 5, 2021

2.7K
Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors
10:29

Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors

Published on: May 9, 2025

998
Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds
09:29

Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds

Published on: October 29, 2015

30.2K

Area of Science:

  • Virology
  • Drug Discovery
  • Computational Chemistry

Background:

  • The high contagiousness of SARS-CoV-2 and the absence of specific treatments necessitate exploring existing drugs.
  • Coinfection studies with HIV suggested antiretroviral drugs might offer protection against SARS-CoV-2.

Purpose of the Study:

  • To investigate potential SARS-CoV-2 therapeutics by evaluating interactions between existing antiretroviral drugs and viral targets.
  • To identify molecules that could inhibit SARS-CoV-2 replication or entry.

Main Methods:

  • Molecular docking studies were employed to analyze interactions between common antiretroviral drugs and critical SARS-CoV-2 proteins.
  • Specific targets included the main protease, RNA polymerase, and the angiotensin-converting-enzyme 2 (ACE2) receptor.

Main Results:

  • Contrary to initial hypotheses, antiretroviral drugs did not show significant interactions.
  • Cobicistat and ritonavir, inhibitors of cytochrome P450, demonstrated strong binding affinity to SARS-CoV-2 main protease and RNA polymerase.
  • These compounds also interacted with the ACE2 receptor, crucial for viral entry.

Conclusions:

  • Cobicistat and ritonavir show potential as preventive agents against SARS-CoV-2 infection.
  • These findings suggest repurposing cobicistat and ritonavir for COVID-19 prevention strategies.