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Prevalence of Fosfomycin Resistance Among Enterobacterales Isolates in A Tertiary Care Hospital from Turkey

Yeliz Tanrıverdi-Çaycı1, Doğa Beliz Güne2, Mustafa Ertokatlı2

  • 1Department of Medical Microbiology, Ondokuz Mayıs University School of Medicine, Samsun, Turkey.

Infectious Diseases & Clinical Microbiology
|April 18, 2024
PubMed
Abstract

Insights

Fosfomycin effectively treats urinary tract infections caused by E. coli, but resistance is increasing. This study tracked fosfomycin resistance in Enterobacterales over nine years, revealing concerning trends that warrant further investigation.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Pharmacology

Background:

  • Urinary tract infections (UTIs) are a global health concern.
  • Fosfomycin is a key antibiotic for treating UTIs.
  • Rising fosfomycin resistance in Enterobacterales necessitates monitoring.

Purpose of the Study:

  • To analyze the distribution of uropathogenic Enterobacterales.
  • To determine fosfomycin resistance rates over nine years (2012-2020).

Main Methods:

  • Analysis of 18,884 uropathogenic Enterobacterales isolates.
  • Identification and antimicrobial susceptibility testing using VITEK® 2 Compact and VITEK® MS systems.

Main Results:

  • Escherichia coli was the most prevalent pathogen (64.04%).
  • Overall fosfomycin resistance was 10.36%, with higher rates in Klebsiella pneumoniae (21.64%).
  • Extended-spectrum β-lactamase (ESBL)-producing Enterobacterales showed 13.08% fosfomycin resistance.

Conclusions:

  • Fosfomycin remains effective against E. coli UTIs.
  • A significant increase in fosfomycin resistance was observed over the study period.
  • Further research into fosfomycin resistance mechanisms and trends is recommended.
Keywords:
Enterobacteralesextended-spectrum beta-lactamases producingfosfomycin resistance

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