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The association between diabetes mellitus and musculoskeletal disorders: a systematic review and meta-analysis

Mobin Azami1, Asra Moradkhani1, Maryam Afraie2

  • 1Student of the Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran.

Frontiers in Endocrinology
|April 18, 2024
PubMed
Abstract

Insights

This meta-analysis found a slight association between diabetes mellitus (DM) and musculoskeletal disorders (MSDs). Further research is needed to understand the mechanisms and develop interventions for managing MSDs in diabetic patients.

Area of Science:

  • Endocrinology
  • Rheumatology
  • Public Health

Background:

  • Diabetes Mellitus (DM) is a growing global health concern with increasing patient longevity.
  • Musculoskeletal Disorders (MSDs) are common but under-researched comorbidities in diabetic populations.
  • Existing research lacks comprehensive data on the prevalence and association of MSDs in individuals with DM.

Approach:

  • Systematic review and meta-analysis of cohort studies.
  • Comprehensive search of major scientific databases (PubMed, Web of Science, Scopus, Embase) up to June 2023.
  • Inclusion of ten cohort studies with 308,445 participants.

Key Points:

  • A pooled risk ratio (RR) of 1.03 (95% CI 1.00-1.06) suggests a potential association between MSDs and DM.
  • Subgroup analysis indicated a higher association in patients with longer diabetes duration (>7 years), European ethnicity, age <70, and females.
  • Findings highlight the importance of recognizing and managing MSDs in the diabetic population.

Conclusions:

  • The meta-analysis indicates a possible link between diabetes mellitus and musculoskeletal disorders.
  • These results underscore the need for increased awareness and proactive management of MSDs in individuals with diabetes.
  • Further investigation into underlying mechanisms and targeted interventions is crucial for prevention and treatment.
Keywords:
complicationsdiabetes mellitusevidence synthesismeta-analysismusculoskeletal disorders

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