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Keap1-Nrf2 pathway: a key mechanism in the occurrence and development of cancer

Feilong Chen1, Mei Xiao2, Shaofan Hu3

  • 1Sports Medicine Key Laboratory of Sichuan Province, Expert Centre of Sichuan Province, Institute of Sports Medicine and Health, Chengdu Sport University, Chengdu, China.

Frontiers in Oncology
|April 18, 2024
PubMed

Insights

The Keap1-Nrf2 pathway regulates cell protection but can also promote cancer growth. Understanding this pathway is crucial for developing new cancer treatments and prevention strategies.

Area of Science:

  • Molecular Biology
  • Cellular Biology
  • Oncology

Background:

  • The Keap1-Nrf2 signaling pathway is a critical regulator of cellular defense against oxidative and electrophilic stress.
  • Reactive oxygen species (ROS) play a significant role in cellular damage and are implicated in various diseases.

Purpose of the Study:

  • To review and summarize the literature on the Keap1-Nrf2 signaling pathway.
  • To explore its structure, function, and role in cancer development and clinical applications.

Main Methods:

  • Literature review and synthesis of existing research on the Keap1-Nrf2 pathway.
  • Analysis of the pathway's dual role in cytoprotection and cancer progression.

Main Results:

  • The Keap1-Nrf2 pathway exhibits a dual role: cytoprotective under normal conditions and promoting cancer cell survival and proliferation when dysregulated.
  • Aberrant Keap1-Nrf2 signaling is observed in multiple human cancers, including lung, liver, and thyroid cancer.
  • Oxidative stress, a key factor in the pathway, is also a recognized marker for human cancers.

Conclusions:

  • The Keap1-Nrf2 pathway is a significant factor in cancer pathogenesis and progression.
  • Further research into the molecular mechanisms of this pathway is vital for advancing cancer prevention and therapeutic strategies.
  • Targeting the Keap1-Nrf2 pathway holds potential for novel cancer treatments.
Keywords:
Keap1Nrf2cancerclinicalfunctionpreventionstructuretranscriptional regulation

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