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Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
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Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

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Renal denervation for uncontrolled hypertension: a systematic review and meta-analysis examining multiple subgroups

Andrew S P Sharp1, Alice Sanderson2, Neil Hansell2

  • 1University Hospital of Wales and Cardiff University.

Journal of Hypertension
|April 18, 2024
PubMed

Insights

Renal denervation (RDN) effectively lowers blood pressure in patients with uncontrolled hypertension. This procedure shows consistent results, even in those with treatment-resistant hypertension.

Area of Science:

  • Cardiology
  • Nephrology
  • Interventional Cardiology

Background:

  • Uncontrolled arterial hypertension remains a significant global health concern.
  • Randomized controlled trials (RCTs) provide crucial evidence for treatment efficacy.
  • Renal denervation (RDN) is an emerging interventional therapy for hypertension.

Approach:

  • A systematic review and meta-analysis of RCTs was performed.
  • Twenty-five RCTs were included in the systematic review.
  • Sixteen RCTs were synthesized in the meta-analysis to assess RDN's impact on blood pressure.

Key Points:

  • RDN demonstrated a significant reduction in office systolic blood pressure (SBP) by -8.5 mmHg.
  • Ambulatory blood pressure also showed marked decreases: 24-hour SBP by -3.6 mmHg and daytime SBP by -3.9 mmHg.
  • Consistent blood pressure reductions were observed across subgroups, including those with treatment-resistant hypertension.

Conclusions:

  • This meta-analysis supports RDN as an effective treatment for uncontrolled hypertension.
  • RDN achieves statistically consistent blood pressure reductions, irrespective of concomitant medications.
  • The findings highlight RDN's potential in managing medication-resistant hypertension.

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