Molecular Transducers of Physical Activity Consortium (MoTrPAC): human studies design and protocol

Area of Science:

• Exercise physiology and molecular biology
• Biomedical research on physical activity and health

Background:

• Structured exercise is linked to improved chronic disease outcomes.
• Molecular pathways mediating exercise benefits are not fully understood.
• A comprehensive molecular map of exercise responses is needed.

Purpose of the Study:

• To isolate the effects of structured exercise training on molecular mechanisms.
• To create a molecular map of exercise responses for health benefits.
• To establish a foundation for Precision Exercise Medicine research.

Main Methods:

• The Molecular Transducers of Physical Activity Consortium (MoTrPAC) human studies involve adult and pediatric components.
• Adults are randomized to control, endurance, or resistance exercise groups for 12 weeks.
• Biospecimens are collected during acute exercise sessions for molecular analysis.

Main Results:

• This study presents the design, protocols, and procedures for the MoTrPAC human studies.
• Data will be collected on various phenotyping measures including fitness and body composition.
• The study will generate a compendium of molecular responses to different exercise types.

Conclusions:

• MoTrPAC is the first large trial to isolate molecular mechanisms of exercise benefits.
• The findings will inform future research and establish a data repository for the scientific community.
• This work will pave the way for a new era in Precision Exercise Medicine.