Mannose Binding Lectin and C3 Serum Levels in Coronary Artery Disease: A Cross-Sectional Study

Area of Science:

• Immunology
• Cardiology
• Biochemistry

Background:

• Coronary artery disease (CAD) involves tissue injury linked to complement system activation.
• Mannose-binding lectin (MBL) and C3 are complement proteins found in atherosclerotic lesions.

Purpose of the Study:

• To measure serum levels of MBL and C3 in CAD patients and healthy controls.
• To investigate the association between MBL and C3 levels and cardiometabolic parameters in CAD.

Main Methods:

• Serum MBL and C3 concentrations were quantified using ELISA and immunoturbidimetry.
• The study included 119 CAD patients (48 with acute myocardial infarction) and 93 healthy controls.

Main Results:

• CAD patients exhibited significantly higher MBL serum concentrations compared to controls (p=.002).
• Elevated MBL levels (>2000 ng/mL) were more prevalent in CAD patients (OR=2.6).
• C3 levels showed no significant difference between groups but correlated positively with BMI and triglycerides.

Conclusions:

• Elevated MBL concentrations are associated with the presence of CAD.
• C3 levels are linked to cardiovascular risk factors rather than CAD directly.