The genetics of schizophrenia: new perspectives

Despite the evidence for genetic factors in schizophrenia, the underlying hereditary defect is unknown. The author reviews recent advances in genetic research methodologies and discusses their strengths and limitations. He concludes that in the face of genetic heterogeneity current models of segregation analysis are not likely to unravel the mode of inheritance of schizophrenia. The author underscores the potential contribution of both molecular genetics (as a means to generate DNA markers) and studies with biologic vulnerability traits to identifying and quantitating the genetic component in the transmission of schizophrenia.