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Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
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Circadian Disruption as a Risk Factor for Development of Cardiovascular and Metabolic Disorders - From Animal Models
1Laboratory of Biological Rhythms, Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic. alena.sumova@fgu.cas.cz.
Physiological Research
|April 18, 2024
Summary
Modern lifestyles disrupt natural body rhythms, increasing risks for cardiovascular and metabolic disorders. Understanding circadian clock function is key to preventing these diseases of civilization.
Area of Science:
- Chronobiology
- Human Physiology
- Pathology
Background:
- Human lifestyle increasingly diverges from natural environmental and solar cycles.
- Disruption of daily rhythms, including late-night activity and eating, negatively impacts internal temporal organization.
- This misalignment is linked to the rise of 'diseases of civilization'.
Purpose of the Study:
- To review research on the link between circadian regulation disruption and health.
- To focus on the impact of chronodisruption on cardiovascular and metabolic disorders.
- To assess evidence for causality between circadian clock disruption and pathology.
Main Methods:
- Review of selected laboratory studies, including those using spontaneously hypertensive rats.
- Analysis of relevant human studies.
- Assessment of evidence for causality between disrupted circadian rhythms and disease.
Main Results:
- Circadian clock disruption is associated with increased risk of cardiovascular and metabolic disorders.
- Evidence suggests a causal link between chronodisruption and pathology in both animal models and humans.
- Factors like social jetlag and altered chronotype contribute to health issues.
Conclusions:
- Misalignment with daily circadian rhythms significantly impacts health.
- Circadian clock disruption is a contributing factor to cardiovascular and metabolic diseases.
- Further research is warranted to fully elucidate the causal pathways and develop preventative strategies.
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