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Preparation of Binary and Ternary Deep Eutectic Systems
Published on: October 31, 2019
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Eutectic solutions for healing: a comprehensive review on therapeutic deep eutectic solvents (TheDES)
Sudhanshu Kalantri1, Amisha Vora1
1Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, Shri Vile Parle Kelavani Mandal's Narsee Monjee Institute of Management Studies, Mumbai, India.
Drug Development and Industrial Pharmacy
|April 18, 2024
Summary
Deep eutectic solvents (DES) enhance drug delivery and solubility. This review highlights their advantages, including low toxicity and biodegradability, for pharmaceutical applications.
Area of Science:
- Pharmaceutical Science
- Materials Science
Background:
- Deep Eutectic Solvents (DES) are formed by mixing Hydrogen Bond Donors (HBD) and Hydrogen Bond Acceptors (HBA).
- DES offer unique properties like low toxicity, biodegradability, and biocompatibility.
- These solvents have shown potential in enhancing drug solubility, permeability, and delivery.
Purpose of the Study:
- To review the advantages of Deep Eutectic Solvents (DES) in pharmaceutical applications.
- To highlight the role of DES in improving the delivery of poorly soluble active pharmaceutical ingredients (APIs).
Main Methods:
- A systematic literature review was conducted.
- Relevant papers were identified from indexed databases.
- Studies were selected based on significance, quality, and approach.
Main Results:
- Various DES formulations were identified, with components acting as vehicles or APIs.
- DES demonstrated effectiveness in enhancing solubility and delivery for diverse APIs, including NSAIDs and antifungals.
- The review confirmed the significant advancement DES offer in pharmaceutical research for drug delivery.
Conclusions:
- Deep Eutectic Solvents (DES) present a promising platform for advanced drug formulations and delivery systems.
- Their favorable properties, including low toxicity and biodegradability, support their use in various therapeutic applications.
- The utilization of DES represents a significant step forward in overcoming challenges associated with poorly soluble drugs.
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